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多发性脑海绵状畸形:眩晕的罕见病因。

Multiple Cerebral Cavernous Malformation: An Unusual Cause of Vertigo.

作者信息

Kashaf Nur 'Afeena Al Fahmi Abdul, Lim Chee Chean, Jaafar Rohaizam Japar, Hailani Iskandar

机构信息

Department of Otorhinolaryngology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, 50603 Malaysia.

Department of Otorhinolaryngology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.

出版信息

Indian J Otolaryngol Head Neck Surg. 2024 Oct;76(5):4997-5000. doi: 10.1007/s12070-024-04893-4. Epub 2024 Jul 18.

DOI:10.1007/s12070-024-04893-4
PMID:39376406
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11456071/
Abstract

Cerebral cavernous malformation (CM) is a rare benign vascular lesion of the brain, accounting for only 0.3-0.5% incidence in the population. Among them, only a small portion of the patients have multiple lesions (3-33%). While most lesions are asymptomatic, some patients present with seizures and hemorrhagic events. We present an atypical case of multiple cerebral CM in a patient who presented with vertigo. He did not have apparent neurological signs and symptoms until it was detected through imaging studies. His MRI showed multiple CM, with the largest lesion located in the cerebellopontine angle. A neurological consult was obtained and the patient opted for conservative treatment. He was discharged well on medications and was under active monitoring by both the neurosurgery and otorhinolaryngology teams. Intracranial cavernoma can present as vertigo without classic neurological manifestations. Any atypical presentations should alert the physician to perform further imaging to rule out sinister causes in the brain. To date, there is no reported case of intracranial cavernoma presenting as vertigo in the literature.

摘要

脑海绵状血管畸形(CM)是一种罕见的脑部良性血管病变,在人群中的发病率仅为0.3 - 0.5%。其中,只有一小部分患者有多处病变(3 - 33%)。虽然大多数病变无症状,但一些患者会出现癫痫发作和出血事件。我们报告一例以眩晕为表现的多发性脑海绵状血管畸形的非典型病例。在通过影像学检查发现之前,他没有明显的神经体征和症状。他的磁共振成像(MRI)显示多处脑海绵状血管畸形,最大的病变位于桥小脑角。获得了神经科会诊意见,患者选择保守治疗。他出院时病情稳定,正在接受神经外科和耳鼻喉科团队的积极监测。颅内海绵状血管瘤可表现为眩晕而无典型的神经表现。任何非典型表现都应提醒医生进行进一步的影像学检查,以排除脑部的严重病因。迄今为止,文献中尚无颅内海绵状血管瘤以眩晕为表现的报道。

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Masseter Vestibular evoked myogenic potentials: A new tool to assess the vestibulomasseteric reflex pathway.咬肌前庭诱发肌源性电位:一种评估前庭咬肌反射通路的新工具。
J Otol. 2024 Jan;19(1):46-54. doi: 10.1016/j.joto.2023.12.005. Epub 2023 Dec 29.
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Cavernous Malformation of the Seventh Cranial Nerve: Case Report and Review of Literature.第七颅神经海绵状畸形:病例报告及文献综述
World Neurosurg. 2016 Jul;91:676.e13-21. doi: 10.1016/j.wneu.2016.04.104. Epub 2016 May 4.
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Characteristics of cavernomas of the brain and spine.脑和脊髓血管畸形的特征。
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Acute onset of dizziness caused by a cavernous malformation lateral to the fourth ventricle: a case report.第四脑室旁海绵状血管畸形引起的急性头晕发作:病例报告。
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An analysis of the natural history of cavernous angiomas.海绵状血管瘤的自然病史分析。
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