Laporte Damien, Sagot Isabelle
Centre National de la Recherche ScientifiqueUniversité de Bordeaux-Institut de Biochimie et Génétique Cellulaires, UMR5095, Bordeaux, France.
Physiology (Bethesda). 2025 Mar 1;40(2):0. doi: 10.1152/physiol.00036.2024. Epub 2024 Oct 8.
Quiescence is operationally defined as a reversible proliferation arrest. This cellular state is central to both organism development and homeostasis, and its dysregulation causes many pathologies. The quiescent state encompasses very diverse cellular situations depending on the cell type and its environment. Further, quiescent cell properties evolve with time, a process that is thought to be the origin of aging in multicellular organisms. Microtubules are found in all eukaryotes and are essential for cell proliferation as they support chromosome segregation and intracellular trafficking. Upon proliferation cessation and quiescence establishment, the microtubule cytoskeleton was shown to undergo significant remodeling. The purpose of this review is to examine the literature in search of evidence to determine whether the observed microtubule reorganizations are merely a consequence of quiescence establishment or if they somehow participate in this cell fate decision.
静止状态在操作上被定义为一种可逆的增殖停滞。这种细胞状态对于生物体发育和内稳态都至关重要，其失调会导致许多病理状况。静止状态根据细胞类型及其环境涵盖了非常多样的细胞情况。此外，静止细胞的特性会随时间演变，这一过程被认为是多细胞生物体衰老的起源。微管存在于所有真核生物中，并且对于细胞增殖至关重要，因为它们支持染色体分离和细胞内运输。在增殖停止和静止状态建立后，微管细胞骨架被证明会发生显著重塑。本综述的目的是研究文献以寻找证据，来确定观察到的微管重组仅仅是静止状态建立的结果，还是它们以某种方式参与了这种细胞命运决定。
