Centre National de la Recherche Scientifique, Institut de Biochimie et Génétique Cellulaires, Unité Mixte de Recherche 5095, Université de Bordeaux, CS61390, Bordeaux Cedex, 33077, France.
Curr Genet. 2019 Jun;65(3):695-699. doi: 10.1007/s00294-018-00928-w. Epub 2019 Jan 16.
Quiescence is operationally characterized as a temporary and reversible proliferation arrest. There are many preconceived ideas about quiescence, quiescent cells being generally viewed as insignificant sleeping G1 cells. In fact, quiescence is central for organism physiology and its dysregulation involved in many pathologies. The quiescent state encompasses very diverse cellular situations depending on the cell type and its environment. This diversity challenges not only quiescence uniformity but also the universality of the molecular mechanisms beyond quiescence regulation. In this mini-perspective, we discuss recent advances in the concept of quiescence, and illustrate that this multifaceted cellular state is gaining increasing attention in many fields of biology.
静止期是一种暂时的、可逆的增殖停滞状态，其操作特征为。关于静止期有许多先入为主的观念，通常将静止期细胞视为无意义的休眠 G1 期细胞。事实上，静止期对生物体的生理学至关重要，其失调与许多病理有关。静止期状态包含了非常多样化的细胞情况，具体取决于细胞类型及其所处的环境。这种多样性不仅对静止期调控的分子机制的统一性提出了挑战，也对其普遍性提出了挑战。在这篇专题小述评中，我们讨论了静止期概念的最新进展，并举例说明了这种多方面的细胞状态在生物学的许多领域越来越受到关注。
