ABO 血型抗原分泌表型随着 O 型血和年龄的增长而增加。

Increased expression of ABO blood group antigens secretion phenotype with O blood group and age advances.

机构信息

From the Department of Medical Laboratory Sciences (Obaid, Mohammed), Faculty of Medicine and Health Sciences; from the Department of Medical Microbiology (Obaid), Faculty of Science, Ibb University, from the Department of Medical Laboratories (Obaid, Melhi, Alhomamy, Al-Qodaimi), Faculty of Medical Sciences, International Malaysian University, Ibb, Yemen, and from the Department of Medical Analysis (Saghir, Al-Hroob), Princess Aisha Bint Al-Hussein College of Nursing and Health Sciences, Al-Hussein Bin Talal University, Ma'an, Jordan.

出版信息

Saudi Med J. 2024 Oct;45(10):1064-1070. doi: 10.15537/smj.2024.45.10.20240308.

DOI:10.15537/smj.2024.45.10.20240308

PMID:39379119

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11463560/

Abstract

OBJECTIVES

To ascertain the prevalence of ABH antigen secretors and non-secretors among Yemenis. In addition to explore the factors that may affect the expression of the secretion phenotype.

METHODS

This cross-sectional study was carried out between May and September 2022 on 215 healthy Yemeni individuals at the International Malaysian University, Ibb, Yemen. The participants were tested for blood group antigen on their blood samples using standard test tube method using the suitable ABH antisera. Saliva was collected and tested for secretion using hemagglutination inhibition test with suitable A, B, and H antisera. Before collecting the blood samples, informed consent was obtained from each participant and complete data and history questionnaire were collected by the research team.

RESULTS

In general, 78.1% of Yemini participants were found to be secretor (80% men and 73.3% females). This percentage increased within O blood group (95%) and decreased within AB blood group (54%) individuals. Both O and AB blood groups showed statistically significant association with secretor trait. Also, it was noticed that age advance increases the expression of gene. In addition, the secretor state increased among Rh-negative people.

CONCLUSION

The frequency of ABH secretors was 78.1% among Ibb province population in Yemen. Blood group O revealed the greatest frequency (95%), whereas blood group AB showed the lowest secretor frequency (54%). The secretor phenotype was highly expressed gradually with advance age then decline.

摘要

目的

确定也门人群中 ABH 抗原分泌者和非分泌者的流行率。此外，还探讨了可能影响分泌表型表达的因素。

方法

这是一项在 2022 年 5 月至 9 月期间于也门伊卜国际马来西亚大学进行的横断面研究，共纳入了 215 名健康的也门个体。使用标准试管法在血液样本上检测血型抗原，使用合适的 ABH 抗血清。采集唾液样本，使用合适的 A、B 和 H 抗血清进行血凝抑制试验检测分泌情况。在采集血液样本之前，每个参与者都获得了知情同意，研究团队收集了完整的数据和病史问卷。