State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, P. R. China.
Shanghai Key Laboratory of Sleep Disordered Breathing, Department of Otolaryngology-Head and Neck Surgery, Otolaryngology Institute of Shanghai JiaoTong University, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.
Nat Commun. 2024 Oct 8;15(1):8462. doi: 10.1038/s41467-024-52354-x.
In surgical medicine, suturing is the standard treatment for large incisions, yet traditional sutures are limited in functionality. Electrical stimulation is a non-pharmacological therapy that promotes wound healing. In this context, we designed a passive and biodegradable mechanoelectric suture. The suture consists of multi-layer coaxial structure composed of (poly(lactic-co-glycolic acid), polycaprolactone) and magnesium to allow safe degradation. In addition to the excellent mechanical properties, the mechanoelectrical nature of the suture grants the generation of electric fields in response to movement and stretching. This is shown to speed up wound healing by 50% and reduce the risk of infection. This work presents an evolution of the conventional wound closure procedures, using a safe and degradable device ready to be translated into clinical practice.
在外科医学中，缝合是处理大切口的标准治疗方法，但传统的缝线在功能上存在局限性。电刺激是一种非药物治疗方法，可促进伤口愈合。在这种情况下，我们设计了一种被动和可生物降解的机电缝合线。该缝合线由多层同轴结构组成，由（聚（乳酸-共-乙醇酸）、聚己内酯）和镁组成，以确保安全降解。除了出色的机械性能外，缝合线的机电性质还允许其在运动和拉伸时产生电场。这被证明可以将伤口愈合速度提高 50%，并降低感染风险。这项工作代表了传统伤口闭合程序的演变，使用了一种安全且可降解的装置，准备好转化为临床实践。
