Lin Yuhai, Lin Wenhao, Lai Yucheng, Chen Yuqiang
Department of General Surgery, Shantou Central Hospital, Shantou, China.
Department of Part-Time Master of Business Administration, Antai College of Economics and Management, Shanghai Jiao Tong University, Shanghai, China.
Biol Trace Elem Res. 2025 Jun;203(6):3445-3454. doi: 10.1007/s12011-024-04413-z. Epub 2024 Oct 9.
Copper dysregulation is pivotal in tumorigenesis. This study aimed to elucidate the knowledge framework of copper homeostasis within neoplasms utilizing bibliometric analysis. Publications about copper homeostasis in neoplasms from 2013 to 2023 were retrieved from the Web of Science Core Collection and PubMed databases. The bibliometric analysis was conducted using the RStudio, the CiteSpace software, the VOSviewer software, and a bibliometric analysis platform. A total of 1701 articles were indexed from 73 countries and regions. China has emerged as the leading country with a publication proportion of 32.45%, followed by the USA (10.35%) and India (8.41%). Significant collaborations have been conducted among Chinese academic institutions. The Journal of Inorganic Biochemistry emerged as the most prominent journal. Among the 4841 keywords extracted from 671 journals, concepts of cell death, positron emission tomography, and tumor microenvironment emerged as the most significant hotspots. This bibliometric study reviewed significant academic development and synthesized research trends on copper homeostasis in neoplasms, providing a valuable reference for scholars.
铜代谢失调在肿瘤发生过程中起关键作用。本研究旨在利用文献计量分析阐明肿瘤内铜稳态的知识框架。从Web of Science核心合集和PubMed数据库中检索了2013年至2023年期间关于肿瘤中铜稳态的出版物。使用RStudio、CiteSpace软件、VOSviewer软件和一个文献计量分析平台进行文献计量分析。共索引了来自73个国家和地区的1701篇文章。中国已成为领先国家，发表比例为32.45%，其次是美国（10.35%）和印度（8.41%）。中国学术机构之间开展了重要合作。《无机生物化学杂志》成为最突出的期刊。从671种期刊中提取的4841个关键词中，细胞死亡、正电子发射断层扫描和肿瘤微环境的概念成为最显著的热点。这项文献计量研究回顾了肿瘤中铜稳态的重要学术发展并综合了研究趋势，为学者提供了有价值的参考。
