Van Damme M, Molle L, Abi Khalil F
J Toxicol Clin Toxicol. 1985;23(7-8):589-614. doi: 10.3109/15563658508990660.
Some physicochemical treatments of biological samples, before being injected into a liquid chromatograph, are discussed. The advantages of dilution, liquid and solid extraction are compared referring mainly to unpublished results. Assays of antiepileptic drugs, caffeine, theophylline, tricyclic antidepressants, valproic acid, and meprobamate are used to demonstrate the importance of sample handlings in toxicological analyses in which reversed phase high performance liquid chromatographies are applied.
本文讨论了生物样品在注入液相色谱仪之前的一些物理化学处理方法。主要参考未发表的结果，比较了稀释、液液萃取和固相萃取的优点。通过对抗癫痫药物、咖啡因、茶碱、三环类抗抑郁药、丙戊酸和甲丙氨酯的分析，证明了样品处理在应用反相高效液相色谱法进行毒理学分析中的重要性。
