补充β-羟基-β-甲基丁酸（HMB）对成年人血脂水平的影响：一项采用GRADE评估的随机对照试验系统评价与荟萃分析
Effects of β-hydroxy-β-methylbutyrate (HMB) supplementation on lipid profile in adults: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials.
作者信息
Sadeghi Behrad, Bahari Hossein, Jozi Hannane, Hasanzadeh Mohammad-Ali, Hashemi Dorna, Bideshki Mohammad Vesal
机构信息
Department of Agricultural, Forest and Food Science (DISAFA), University of Torino, Grugliasco, Torino, Italy.
Transplant Research Center, Clinical Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Front Nutr. 2024 Sep 25;11:1451282. doi: 10.3389/fnut.2024.1451282. eCollection 2024.
BACKGROUND AND AIM
The regulation of lipid metabolism is crucial for preventing cardiovascular diseases, which are among the leading causes of mortality worldwide. β-hydroxy-β-methylbutyrate (HMB) has garnered attention for its potential role in modulating lipid profiles. However, the magnitude of these effects are unclear due to the heterogeneity of the studies. This study aimed to provide a comprehensive overview of the randomized controlled trials (RCTs) that have examined the effects of HMB on lipid profiles in adults.
METHODS
Databases including PubMed, Web of Science, and Scopus, were searched for relevant studies through January 2024. The study protocol was also registered at Prospero (no. CRD42024528549). Based on a random-effects model, we calculated WMDs and 95% confidence intervals (CIs). The outcomes assessed included total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Sensitivity, subgroup and meta-regression analyses were also conducted.
RESULTS
Our analysis included a total of 10 RCTs comprising 421 participants. The pooled data revealed no significant effect of HMB supplementation on TC (WMD: -2.26 mg/dL; 95%CI: -6.11 to 1.58; = 0.25), TG (WMD: -2.83 mg/dL 95% CI: -12.93 to 7.27; = 0.58), LDL-C (WMD: 0.13 mg/dL; 95%CI: -3.02 to 3.28; mg; = 0.94), and HDL-C (WMD: -0.78 mg/dL; 95%CI: -2.04 to 0.48; = 0.22). The quality of evidence was rated as moderate to low for all outcomes.
CONCLUSION
The current evidence from RCTs suggests that HMB supplementation does not significantly alter lipid profiles, including TC, TG, LDL-C, and HDL-C. Further research is warranted to confirm these results and explore the potential mechanisms of action of HMB.
SYSTEMATIC REVIEW REGISTRATION
https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=528549, CRD42024528549.
背景与目的
脂质代谢的调节对于预防心血管疾病至关重要，心血管疾病是全球主要的死亡原因之一。β-羟基-β-甲基丁酸（HMB）因其在调节血脂方面的潜在作用而受到关注。然而，由于研究的异质性，这些作用的程度尚不清楚。本研究旨在全面概述已考察HMB对成年人血脂影响的随机对照试验（RCT）。
方法
检索了包括PubMed、科学网和Scopus在内的数据库，以查找截至2024年1月的相关研究。研究方案也已在国际系统评价注册库（注册号：CRD42024528549）登记。基于随机效应模型，我们计算了加权均数差（WMD）和95%置信区间（CI）。评估的结局指标包括总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）。还进行了敏感性、亚组和Meta回归分析。
结果
我们的分析共纳入10项RCT，涉及421名参与者。汇总数据显示，补充HMB对TC（WMD：-2.26mg/dL；95%CI：-6.11至1.58；P=0.25）、TG（WMD：-2.83mg/dL；95%CI：-12.93至7.27；P=0.58）、LDL-C（WMD：0.13mg/dL；95%CI：-3.02至3.28；P=0.94）和HDL-C（WMD：-0.78mg/dL；95%CI：-2.04至0.48；P=0.22）均无显著影响。所有结局指标的证据质量被评为中等至低等。
结论
来自RCT的当前证据表明，补充HMB不会显著改变血脂水平，包括TC、TG、LDL-C和HDL-C。有必要进一步研究以证实这些结果，并探索HMB的潜在作用机制。
系统评价注册
https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=528549，CRD42024528549
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