Glick Cameron, Gajawelli Niharika, Sun Yinming, Badami Faizan, Saggar Manish, Etkin Amit
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
bioRxiv. 2024 Sep 26:2024.09.25.614833. doi: 10.1101/2024.09.25.614833.
Neuroimaging and cognitive neuroscience studies have identified neural circuits linked to anxiety, mood, and trauma-related symptoms and focused on their interaction with the medial prefrontal default mode circuitry. Despite these advances, developing new neuromodulatory treatments based on neurocircuitry remains challenging. It remains unclear which nodes within and controlling these circuits are affected and how their impairment is connected to psychiatric symptoms. Concurrent single-pulse (sp) TMS/fMRI offers a promising approach to probing and mapping the integrity of these circuits. In this study, we present concurrent sp-TMS/fMRI data along with structural MRI scans from 152 participants, including both healthy and depressed individuals. The sp-TMS was administered to 11 different cortical sites, providing a dataset that allows researchers to investigate how brain circuits are modulated by spTMS.
神经影像学和认知神经科学研究已经确定了与焦虑、情绪及创伤相关症状有关的神经回路，并关注它们与内侧前额叶默认模式回路的相互作用。尽管取得了这些进展，但基于神经回路开发新的神经调节治疗方法仍然具有挑战性。目前尚不清楚这些回路内部及控制这些回路的哪些节点受到影响，以及它们的损伤如何与精神症状相关联。同步单脉冲（sp）TMS/fMRI为探究和描绘这些回路的完整性提供了一种很有前景的方法。在本研究中，我们展示了来自152名参与者（包括健康个体和抑郁症患者）的同步sp-TMS/fMRI数据以及结构MRI扫描结果。对11个不同的皮质部位进行了sp-TMS，提供了一个数据集，使研究人员能够研究spTMS如何调节脑回路。
