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手术加速康复对初次全膝关节置换术后血液管理的影响:一项倾向评分匹配分析

Impact of enhanced recovery after surgery on postoperative blood management following primary total knee arthroplasty: a propensity score-matched analysis.

作者信息

Mogalli Abdullah S, Zhao Jianbo, Chen Yang, Qi Xin

机构信息

Department of Bone and Joint Surgery, Orthopaedic Center, The First Hospital of Jilin University, Xin-Min Street No. 1, Changchun, 130021, Jilin, China.

出版信息

Int Orthop. 2025 Jan;49(1):53-63. doi: 10.1007/s00264-024-06342-x. Epub 2024 Oct 10.

DOI:10.1007/s00264-024-06342-x
PMID:39387884
Abstract

PURPOSE

To evaluate the efficacy of blood management in patients underwent unilateral Total Knee Arthroplasty (TKA) under an enhanced recovery after surgery (ERAS) program.

METHOD

Patients underwent unilateral TKA from January 2019 to October 2023 in a university hospital were retrospectively studied. A total of 200 cases were selected in the analysis. After matching with propensity scoring, 51 patients in each group were included. The postoperative Haemoglobin (Hb), albumin (Alb), C-reactive protein (CRP), total length of stay (LOS), and estimated blood loss after operation were compared between the two groups. Clinical outcomes including Western Ontario and McMaster Universities Arthritis Index (WOMAC), SF-12, and Oxford Knee Score (OKS) were also compared at six week and three month follow-up.

RESULTS

The results showed that the Hb of the ERAS group was significantly higher than those of the non-ERAS group (P < 0.05) on the third postoperative. The mean CRP level was lower, LOS was shorter, and Alb level was higher in the ERAS group compared to that in the non-ERAS group (P < 0.05). The clinical outcomes such as WOMAC and OKS, SF-12 scores were higher in the ERAS group at both follow-up.

CONCLUSION

ERAS protocol effectively minimizes perioperative blood loss and supports optimal nutrient levels in patients. ERAS management significantly contributes to the postoperative recovery of knee function in patients undergoing primary total knee arthroplasty.

摘要

目的

评估在术后加速康复(ERAS)方案下,单侧全膝关节置换术(TKA)患者血液管理的疗效。

方法

回顾性研究2019年1月至2023年10月在某大学医院接受单侧TKA的患者。分析中共选取200例病例。经倾向评分匹配后,每组纳入51例患者。比较两组患者术后血红蛋白(Hb)、白蛋白(Alb)、C反应蛋白(CRP)、住院总时长(LOS)及术后估计失血量。在术后六周和三个月随访时,还比较了包括西安大略和麦克马斯特大学关节炎指数(WOMAC)、SF-12和牛津膝关节评分(OKS)在内的临床结局。

结果

结果显示,术后第三天,ERAS组的Hb显著高于非ERAS组(P<0.05)。与非ERAS组相比,ERAS组的平均CRP水平更低,LOS更短,Alb水平更高(P<0.05)。在两次随访中,ERAS组的WOMAC、OKS、SF-12等临床结局评分均更高。

结论

ERAS方案有效减少了围手术期失血,并维持患者最佳营养水平。ERAS管理对初次全膝关节置换术患者的膝关节功能术后恢复有显著贡献。

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本文引用的文献

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Predictive and protective factors for allogenic blood transfusion in total knee arthroplasty. A retrospective cohort study.全膝关节置换术中异体输血的预测因素和保护因素。一项回顾性队列研究。
J Orthop. 2023 Apr 21;40:29-33. doi: 10.1016/j.jor.2023.04.015. eCollection 2023 Jun.
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Are 20% of Patients Actually Dissatisfied Following Total Knee Arthroplasty? A Systematic Review of the Literature.全膝关节置换术后有 20%的患者真的不满意吗?文献系统评价。
J Arthroplasty. 2023 Mar;38(3):594-599. doi: 10.1016/j.arth.2022.10.011. Epub 2022 Oct 14.
3
Enhanced recovery after surgery for primary total hip arthroplasty: analysis of post-operative blood indexes.
初次全髋关节置换术后的加速康复:术后血液指标分析
Int Orthop. 2023 Jan;47(1):125-129. doi: 10.1007/s00264-022-05606-8. Epub 2022 Oct 13.
4
Incorporation of Blood and Fluid Management Within an Enhanced Recovery after Surgery Protocol in Complex Spine Surgery.在复杂脊柱手术的术后加速康复方案中纳入血液和液体管理
Global Spine J. 2024 Mar;14(2):639-646. doi: 10.1177/21925682221120399. Epub 2022 Aug 23.
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Complications of total hip or knee arthroplasty are not significantly more common after ambulatory surgery than after in-patient surgery and enhanced recovery: A case-control study with propensity-score matching.关节置换术后门诊手术与住院手术相比,并发症并不更常见,且增强康复:病例对照研究与倾向评分匹配。
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Total knee arthroplasty is associated with greater immediate post-surgical pain and opioid use than total hip arthroplasty.全膝关节置换术比全髋关节置换术引起更大的术后即刻疼痛和阿片类药物使用。
Arch Orthop Trauma Surg. 2022 Dec;142(12):3575-3580. doi: 10.1007/s00402-021-03951-8. Epub 2021 May 15.
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Enhanced recovery short-stay hip and knee joint replacement program improves patients outcomes while reducing hospital costs.强化康复短期髋膝关节置换项目可改善患者预后,同时降低医院成本。
Orthop Traumatol Surg Res. 2019 Nov;105(7):1237-1243. doi: 10.1016/j.otsr.2019.08.013. Epub 2019 Oct 3.
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Tourniquet Use in Total Knee Arthroplasty.全膝关节置换术中止血带的使用
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Special Article: 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis.特稿:2018 年美国风湿病学会/国家银屑病基金会银屑病关节炎治疗指南。
Arthritis Rheumatol. 2019 Jan;71(1):5-32. doi: 10.1002/art.40726. Epub 2018 Nov 30.
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Enhanced recovery after surgery for hip and knee arthroplasty: a systematic review and meta-analysis.髋关节和膝关节置换术后的加速康复:系统评价和荟萃分析。
Postgrad Med J. 2017 Dec;93(1106):736-742. doi: 10.1136/postgradmedj-2017-134991. Epub 2017 Jul 27.