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耐腐蚀多任务细胞染色机的设计与实现。

Design and implementation of corrosion-resistant multitasking cell stainers.

机构信息

School of Electronics and Electrical Engineering, Wuhan Textile University, Wuhan, Hubei, China.

Hubei Province Engineering Research Center for Intelligent Micro-Nano Medical Equipment and Key Technologies, Wuhan, Hubei, China.

出版信息

PLoS One. 2024 Oct 10;19(10):e0309334. doi: 10.1371/journal.pone.0309334. eCollection 2024.

Abstract

Compared with machine staining, traditional manual staining faces various problems, such as a low preparation success rate, low efficiency, and harm to the human body due to corrosive gases. Therefore, a stainer that is of low cost, has strong corrosion resistance, and is suitable for small-batch preparation should be developed. In this study, by choosing a rotary scheme as the structural basis, a reusable container cover and a master-slave manipulator cooperation scheme are developed, which greatly improve the space utilization rate. Through material selection and structural design, in the designed stainer, effective protection against strong acids with high volatility and permeability is realized, thereby eliminating the corrosion issue. Using the designed splitting-running algorithm for the dyeing procedure, simultaneous multistaining is realized, which significantly improves the staining efficiency. Compared with large-sized stainers, the cost of the proposed stainer is very low, which will help popularize early screening for cervical cancer in low- and middle-income countries.

摘要

与机器染色相比,传统的手动染色面临着各种问题,如准备成功率低、效率低以及由于腐蚀性气体对人体造成的伤害。因此,应该开发一种成本低、耐腐蚀性强、适合小批量制备的染色机。在本研究中,通过选择旋转方案作为结构基础,开发了可重复使用的容器盖和主从机械手协作方案,从而大大提高了空间利用率。通过材料选择和结构设计,在设计的染色机中实现了对高挥发性和高渗透性强酸的有效保护,从而消除了腐蚀问题。使用设计的分割运行算法进行染色程序,实现了同时进行多步染色,显著提高了染色效率。与大型染色机相比,所提出的染色机的成本非常低,这将有助于在中低收入国家推广宫颈癌的早期筛查。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e760/11466404/8d4b6eb1e7ad/pone.0309334.g001.jpg

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