Department of Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR), 10589 Berlin, Germany.
Department of Surgery, Hamad Medical Corporation (HMC), Doha 3050, Qatar.
Biomed Mater. 2024 Oct 18;19(6). doi: 10.1088/1748-605X/ad85bb.
The pursuit of sustainable bioinspired materials for regenerative medicine demands a nuanced balance between scientific advancement, ethical considerations, and environmental consciousness. This abstract encapsulates a comprehensive perspective paper exploring the intricate dynamics of toxicology, environmental impact, and ethical concerns within the realm of bioinspired materials. As the landscape of regenerative medicine evolves, ensuring the biocompatibility and safety of these materials emerges as a pivotal challenge. Our paper delves into the multidimensional aspects of toxicity assessment, encompassing cytotoxicity, genotoxicity, and immunotoxicity analyses. Additionally, we shed light on the complexities of evaluating the environmental impact of bioinspired materials, discussing methodologies such as life cycle assessment, biodegradability testing, and sustainable design approaches. Amid these scientific endeavors, we emphasize the paramount importance of ethical considerations in bioinspired material development, navigating the intricate web of international regulations and ethical frameworks guiding medical materials. Furthermore, our abstract underscores the envisioned future directions and challenges in toxicology techniques, computational modeling, and holistic evaluation, aiming for a comprehensive understanding of the synergistic interplay between sustainable bioinspired materials, toxicity assessment, environmental stewardship, and ethical deliberation.
追求可持续的仿生再生医学材料需要在科学进步、伦理考量和环境意识之间取得微妙的平衡。本文是一篇全面的观点综述论文，探讨了毒理学、环境影响和仿生材料领域的伦理问题之间复杂的动态关系。随着再生医学领域的发展，确保这些材料的生物相容性和安全性成为一个关键的挑战。本文深入探讨了毒性评估的多维度方面，包括细胞毒性、遗传毒性和免疫毒性分析。此外，我们还介绍了评估仿生材料环境影响的复杂性，讨论了生命周期评估、生物降解性测试和可持续设计方法等方法。在这些科学努力中，我们强调了在仿生材料开发中考虑伦理因素的至关重要性，以及指导医用材料的国际法规和伦理框架的复杂性。此外，本文还强调了毒理学技术、计算建模和整体评估的未来发展方向和挑战，旨在全面了解可持续仿生材料、毒性评估、环境管理和伦理审议之间的协同作用。
