Cheong Sousan, Yang Han, Hao Choukuan, Lu Feng, He Yunfan
Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangdong, China.
Department of Plastic Surgery, Centro Hospitalar Conde de Sao Januario, Macao Special Administrative Region, China.
Aesthetic Plast Surg. 2024 Nov;48(22):4693-4701. doi: 10.1007/s00266-024-04417-z. Epub 2024 Oct 10.
Numerous intrinsic and extrinsic factors, notably the aging process, contribute to the development of infraorbital dark circles. These features, commonly associated with old age and fatigue, are caused by a disruption of dermal melanin and impairment of skin barrier function. Common aesthetic concerns affecting patients with infraorbital dark circles are primarily owing to lean and translucent lower eyelid skin overlying the orbicularis oculi muscle. This study aimed to present a novel technique for correcting infraorbital dark circles utilizing an adipose-derived extracellular matrix concentrate-adipose collagen fragment (ACF)-to correct infraorbital dark circles.
Female patients (n = 94) aged 20-38 who presented infraorbital dark circles were enrolled to assess the efficacy of this technique for an eight-month follow-up. Following intradermal injections with ACF filler, the clinical outcome was determined by responses to GAIS and patient satisfaction surveys. Statistical analysis was performed with the one-way ANOVA test, and a p value of < 0.05 was considered statistically significant.
Patients (n = 92) completed a single treatment session and underwent an eight-month follow-up. Eighty patients (86%) reported being "highly satisfied" or "satisfied" with the outcome and responded that the technique resulted in brighter, tighter, and smoother infraorbital skin. Over 97% of patients were rated as "improved," "much improved" and "Very much improved" throughout the follow-up on GAIS by three independent surgeons (p < 0.05). The statistical analyses demonstrated the percentage differences among groups are highly significant (p < 0.0001). No irregularity or lump was observed during the follow-up. Two patients were excluded from the study due to having undergone cosmetic eyelid surgery.
Intradermal ACF filler represents a novel approach to addressing infraorbital dark circles and yields significantly high patient satisfaction. ACF fillers provide a degree of bio-stimulation, and adipose-derived concentrate is a natural filler with regenerative effects used in periorbital rejuvenation.
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众多内在和外在因素，尤其是衰老过程，会导致眶下黑眼圈的形成。这些特征通常与衰老和疲劳相关，是由真皮黑色素紊乱和皮肤屏障功能受损引起的。影响眶下黑眼圈患者的常见美学问题主要是由于眼轮匝肌上方的下眼睑皮肤薄且半透明。本研究旨在介绍一种利用脂肪源性细胞外基质浓缩物——脂肪胶原片段（ACF）来矫正眶下黑眼圈的新技术。
纳入94例年龄在20 - 38岁且有眶下黑眼圈的女性患者，以评估该技术的疗效，进行为期8个月的随访。在皮内注射ACF填充剂后，通过全球美容改善量表（GAIS）的反应和患者满意度调查来确定临床结果。采用单因素方差分析进行统计分析，p值<0.05被认为具有统计学意义。
92例患者完成了单次治疗并接受了8个月的随访。80例患者（86%）报告对结果“非常满意”或“满意”，并表示该技术使眶下皮肤更明亮、更紧致、更光滑。在随访期间，超过97%的患者被三位独立外科医生根据GAIS评为“改善”“明显改善”和“非常明显改善”（p<0.05）。统计分析表明各组之间的百分比差异非常显著（p<0.0001）。随访期间未观察到不规则或肿块。两名患者因接受过眼部整形手术而被排除在研究之外。
皮内注射ACF填充剂是一种解决眶下黑眼圈的新方法，患者满意度显著较高。ACF填充剂具有一定程度的生物刺激作用，脂肪源性浓缩物是一种用于眶周年轻化的具有再生作用的天然填充剂。
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