Cerrahpaşa Faculty of Medicine, Department of Medical Microbiology, Istanbul University-Cerrahpaşa, 34147, Istanbul, Türkiye.
Republic of Türkiye, Istanbul Provincial Directorate of Health, Ministry of Health, University of Health Science, Kanuni Sultan Suleyman Training and Research Hospital, Kücükcekmece, 34303, Istanbul, Türkiye.
Ann Clin Microbiol Antimicrob. 2024 Oct 10;23(1):93. doi: 10.1186/s12941-024-00750-y.
Determination of SARS-CoV-2 variant is significant to prevent the spreads of COVID-19 disease.
We aimed to evaluate the variants of SARS-CoV-2 rate in positive patients in Kanuni Sultan Suleyman Training and Research Hospital (KSS-TRH), Istanbul, Türkiye between 1st January and 30th November 2021 by using RT-PCR method.
Herein, 825,169 patients were evaluated (male:58.53% and female:41.47%) whether COVID-19 positive or not [( +):21.3% and (-):78.7%] and 175,367 patient was described as positive (53.2%-female and 46.8%-male) by RT-PCR. COVID-19 positive rate is observed highest in the 6-15- and 66-75-year age range. The frequencies were obtained as SARS-CoV-2 positive (without mutation of B.1.1.7 [B.1.1.7 (U.K), E484K, L452R, B.1.351 (S. Africa/Brazil) spike mutations] as 66.1% (n: 115,899), B.1.1.7 Variant as 23.2% (n:40,686), Delta mutation (L452R) variant as 9.8% (n:17,182), B.1.351 variant as 0.8% (n:1370) and E484K as 0.1% (n: 230). In April 2021, general SARS-CoV-2 and B.1.1.7 variant were dominantly observed. Up to July 2021, B.1.617.2 (Delta variant/ Indian variant) and E484K has been not observed. B.1.351 variant of SARS-CoV-2 has been started in February 2021 at the rarest ratio and March 2021 is the top point. September 2021 is the pick point of E484K. African/Brazil variant of SARS-CoV-2 has been started in February 2021 at the rarest ratio and March 2021 is the top point. September 2021 is the pick point of E484K. When the gender type is compared within the variants, women were found to be more prevalent in all varieties.
The meaning of these mutations is very important to understand the transmission capacity of the COVID-19 disease, pandemic episode, and diagnosis of the virus with mutation types. Understanding the variant type is important for monitoring herd immunity and the spread of the disease.
确定 SARS-CoV-2 变体对于预防 COVID-19 疾病的传播至关重要。
我们旨在通过 RT-PCR 方法评估 2021 年 1 月 1 日至 11 月 30 日期间伊斯坦布尔 Kanuni Sultan Suleyman 培训和研究医院（KSS-TRH）中阳性患者中 SARS-CoV-2 变体的比率。
在此，评估了 825,169 名患者（男性：58.53%，女性：41.47%）是否为 COVID-19 阳性（+）：21.3%，（-）：78.7%），175,367 名患者通过 RT-PCR 被描述为阳性（53.2%-女性和 46.8%-男性）。COVID-19 阳性率在 6-15 岁和 66-75 岁年龄组中最高。获得的 SARS-CoV-2 阳性率（无 B.1.1.7 [英国，E484K，L452R，B.1.351（南非/巴西）尖峰突变]突变）为 66.1%（n：115,899），B.1.1.7 变体为 23.2%（n：40,686），Delta 突变（L452R）变体为 9.8%（n：17,182），B.1.351 变体为 0.8%（n：1370），E484K 为 0.1%（n：230）。2021 年 4 月，普遍观察到 SARS-CoV-2 和 B.1.1.7 变体。截至 2021 年 7 月，尚未观察到 B.1.617.2（Delta 变体/印度变体）和 E484K。SARS-CoV-2 的 B.1.351 变体于 2021 年 2 月以最低比例开始，3 月达到顶峰。2021 年 9 月是 E484K 的高峰点。SARS-CoV-2 的非洲/巴西变体于 2021 年 2 月以最低比例开始，3 月达到顶峰。2021 年 9 月是 E484K 的高峰点。在变体内比较性别类型时，发现所有品种中女性更为普遍。
这些突变的意义对于理解 COVID-19 疾病的传播能力、大流行情况以及突变类型的病毒诊断非常重要。了解变体类型对于监测群体免疫和疾病传播很重要。
