Sasaki Yusuke, Matsunami Kunihiro, Kondo Masashi, Matsukuma Eiji, Imamura Atsushi, Kaneko Hideo
Department of Pediatrics, Gifu Prefectural General Medical Center, Noishiki, Gifu 5008717, Japan.
Department of Neonatology, Gifu Prefectural General Medical Center, Noishiki, Gifu 5008717, Japan.
Biomed Rep. 2024 Sep 30;21(6):178. doi: 10.3892/br.2024.1866. eCollection 2024 Dec.
Specific IgE level (sIgE) is an important factor indicating sensitization status in children with food allergies (FAs). The present study aimed to clarify oral food challenge test (OFC) results in children with FAs with sIgE levels ≥100 UA/ml compared with those in children with sIgE <100. The retrospective study analyzed patients who underwent OFC with egg white, cow milk and wheat at Gifu Prefectural general medical center, Gifu, Japan between July 2017 and March 2023. Clinical history, total IgE (tIgE), sIgE and correlation between sIgE, sIgE/tIgE and eliciting dose as the amount of intake protein were examined. In the <100 group, positive OFC showed significantly higher sIgE for egg white, ovomucoid and casein than negative OFC (P<0.05); however, there was no significant difference between positive and negative OFC in the ≥100 group. In the <100 group, positive OFC showed significantly higher sIgE/tIgE for ovomucoid, milk and casein than negative OFC (P<0.05); however, there was no significant difference in sIgE/tIgE between positive and negative OFC in the ≥100 group. There was a significant negative correlation between eliciting dose and sIgE for egg white and wheat (P<0.05). For milk and wheat, there was no significant difference between ≥100 group and the <100 group with regard to positive rates in the OFC. Therefore, OFC may be safely performed by decreasing total challenge dose for the ≥100 group.
特异性IgE水平（sIgE）是指示食物过敏（FA）儿童致敏状态的一个重要因素。本研究旨在阐明sIgE水平≥100 UA/ml的FA儿童与sIgE<100的儿童相比，口服食物激发试验（OFC）的结果。这项回顾性研究分析了2017年7月至2023年3月期间在日本岐阜县综合医疗中心接受蛋清、牛奶和小麦OFC的患者。检查了临床病史、总IgE（tIgE）、sIgE以及sIgE、sIgE/tIgE与作为摄入蛋白量的激发剂量之间的相关性。在<100组中，OFC阳性组蛋清、卵类粘蛋白和酪蛋白的sIgE显著高于OFC阴性组（P<0.05）；然而，在≥100组中，OFC阳性组和阴性组之间没有显著差异。在<100组中，OFC阳性组卵类粘蛋白、牛奶和酪蛋白的sIgE/tIgE显著高于OFC阴性组（P<0.05）；然而，在≥100组中，OFC阳性组和阴性组之间的sIgE/tIgE没有显著差异。蛋清和小麦的激发剂量与sIgE之间存在显著负相关（P<0.05）。对于牛奶和小麦，≥100组和<100组在OFC阳性率方面没有显著差异。因此，对于≥100组，通过降低总激发剂量可以安全地进行OFC。
