SAHCo. Ltd., Lancashire, United Kingdom.
EBRC Consulting GmbH, 30659, Hannover, Germany.
Regul Toxicol Pharmacol. 2024 Dec;154:105717. doi: 10.1016/j.yrtph.2024.105717. Epub 2024 Oct 11.
In this paper we present methodological and experimental details and results from an OECD Test Guideline 474 and GLP-compliant in vivo micronucleus study on sodium molybdate dihydrate in Sprague Dawley rats. Prior to the conduct of this study, there was a data-gap for reliable in vivo genotoxicity data for molybdenum substances. The presentation of the new study is complemented by a review of other available in vitro and in vivo data on the genotoxicity of molybdenum substances, focussing on substances where the contained or released molybdate ion, MoO, is considered the responsible moiety for any toxicological effect (grouping/category approach). After consideration of the relevance and reliability of all available data, the absence of a concern for genotoxicity of molybdate in vitro and in vivo is concluded.
本文介绍了 OECD 测试指南 474 和 GLP 规定的在 Sprague Dawley 大鼠体内进行二水合钼酸钠的体内微核试验的方法学和实验细节及结果。在进行这项研究之前，对于钼物质的可靠体内遗传毒性数据存在数据空白。新研究的介绍还结合了对其他可用的钼物质遗传毒性的体外和体内数据的审查，重点关注那些被认为是任何毒理学效应的责任部分的含或释放的钼酸盐离子（MoO ）的物质（分组/类别方法）。在考虑了所有可用数据的相关性和可靠性后，得出结论认为钼酸盐在体外和体内均无遗传毒性。
