Department of Medical Laboratory Sciences, School of Allied Health Sciences, University of Health and Allied Sciences, Ho, Ghana.
Department of Biomedical Sciences, School of Basic and Biomedical Sciences, University of Health and Allied Sciences, Ho, Ghana.
J Clin Lab Anal. 2024 Nov;38(22):e25114. doi: 10.1002/jcla.25114. Epub 2024 Oct 14.
Wound infections are often underestimated issues that can lead to chronic illnesses, and since the introduction of antibiotics, wound complications have become less common. However, due to the increased and irrational use of these antibiotics, the resistance in the bacterial isolates has become very common. This has led to reduced treatment options, delay in wound healing, and high treatment costs. This study aimed to investigate bacterial wound infections and their antibiotic resistance at St. Dominic Hospital, Ghana.
A total of 517 records of wound swab culture and susceptibility testing, and patient demographics from 2020 to 2022 were collected from the microbiology unit of St. Dominic Hospital in the Eastern Region of Ghana. The data were entered into Microsoft Excel 2019, cleaned, and exported into IBM SPSS v26 for the statistical analysis. p < 0.05 was considered statistically significant for all analyses.
The overall prevalence of bacteriological agents causing wound infection in individuals who visited the St. Dominic Hospital from 2020 to 2022 was 70.21% (363/517), with S. aureus 79/363 (21.76%) being the most abundant isolate. Out of the 79 S. aureus isolated, 40 (50.63%) and 39 (49.37%) were resistant to ampicillin and cephalexin, respectively. More than 50% of the predominant Gram-negative isolate, K. pneumoniae, were resistant to clindamycin 45/72 (62.50%) but susceptible to levofloxacin 70/72 (97.22%), cefotetan 69/72 (95.83%), and chloramphenicol 67/72 (93.06%).
Antibacterial susceptibility patterns revealed significant resistance trends, particularly among Gram-negative isolates, emphasizing the urgent need for prudent antibiotic use and ongoing surveillance to combat resistance.
伤口感染常常被低估，可能导致慢性病，而且自从抗生素问世以来，伤口并发症已变得不那么常见。然而，由于这些抗生素的使用增加且不合理，细菌分离株的耐药性变得非常普遍。这导致治疗选择减少、伤口愈合延迟和治疗费用增加。本研究旨在调查加纳圣多明各医院的细菌伤口感染及其抗生素耐药性。
从 2020 年至 2022 年，从加纳东部地区圣多明各医院的微生物学部门收集了 517 份伤口拭子培养和药敏试验记录以及患者人口统计学资料。将数据输入 Microsoft Excel 2019，进行清理，然后导出到 IBM SPSS v26 进行统计分析。所有分析均认为 p<0.05 具有统计学意义。
2020 年至 2022 年期间，前往圣多明各医院就诊的个体中，引起伤口感染的细菌病原体的总体患病率为 70.21%（363/517），其中 S. aureus 79/363（21.76%）是最丰富的分离株。在 79 株分离的金黄色葡萄球菌中，分别有 40（50.63%）和 39（49.37%）对氨苄西林和头孢氨苄耐药。主要革兰氏阴性分离株 K. pneumoniae 中超过 50%的菌株对克林霉素耐药 45/72（62.50%），但对左氧氟沙星 70/72（97.22%）、头孢替坦 69/72（95.83%）和氯霉素 67/72（93.06%）敏感。
抗菌药物敏感性模式显示出显著的耐药趋势，尤其是在革兰氏阴性分离株中，这强调了迫切需要谨慎使用抗生素并进行持续监测以对抗耐药性。
