Gottschalk Frode, Gennser Mikael, Eiken Ola, Elia Antonis
Division of Environmental Physiology, Swedish Aerospace Physiology Centre, KTH Royal Institute of Technology, Stockholm, Sweden.
Department of Neuroscience, Experimental Traumatology, KI Karolinska Institutet, Stockholm, Sweden.
Clin Physiol Funct Imaging. 2025 Jan;45(1):e12911. doi: 10.1111/cpf.12911. Epub 2024 Oct 13.
There is a scarcity of information regarding the effect of upper-body eccentric exercise on biomarkers of muscle damage. This study sought to investigate the effect of eccentric arm cycling on muscle damage [exercise-induced muscle damage (EIMD)].
Ten subjects performed a 15 min eccentric arm cycling protocol (cadence 49 ± 7 rpm, power absorbed 248 ± 34 W). Maximal voluntary contraction (MVC) of the elbow flexors was evaluated at rest and at 5 min, 24 h, and 48 h post-exercise. In addition, blood samples were drawn at rest and thereafter at 30 min, 24 h, and 48 h intervals after exercise for quantification of creatine kinase (CK), myoglobin, lactate dehydrogenase (LDH) and endothelin (ET-1) concentrations. Delayed onset muscle soreness (DOMS) was assessed using a category ratio scale (0-10).
Myoglobin was increased from baseline at 30 min post-exercise (+114%, 46.08 ± 22.17 µg/L, p = 0.018). Individual peak values were higher than baseline values for CK (+72.8%, 204 ± 138 U/L, p = 0.046) and LDH (+17%, 3.3 ± 0.88 nmole/min/mL, p = 0.017), but not for ET-1 (+9%, 1.4 ± 0.48 pg/mL, p = 0.45). DOMS was reported at 24 h (median 4) and 48 h (median 4) post-exercise and MVC of the elbow flexors were reduced from baseline (216 ± 44 N) at 5 min (-34%, 147 ± 61 N, p < 0.001), 24 h (-17%, 181 ± 56 N, p = 0.005) and 48 h (-9%, 191 ± 54 N, p = 0.003).
Eccentric arm cycling incites EIMD with reduced MVC and elevation of myoglobin, CK and LDH.
关于上身离心运动对肌肉损伤生物标志物影响的信息匮乏。本研究旨在调查离心手臂骑行对肌肉损伤[运动诱导的肌肉损伤（EIMD）]的影响。
10名受试者进行了15分钟的离心手臂骑行方案（踏频49±7转/分钟，吸收功率248±34瓦）。在休息时以及运动后5分钟、24小时和48小时评估肘屈肌的最大自主收缩（MVC）。此外，在休息时以及运动后每隔30分钟、24小时和48小时采集血样，以定量肌酸激酶（CK）、肌红蛋白、乳酸脱氢酶（LDH）和内皮素（ET-1）的浓度。使用类别比率量表（0-10）评估延迟性肌肉酸痛（DOMS）。
运动后30分钟肌红蛋白较基线升高（+114%，46.08±22.17微克/升，p = 0.018）。CK（+72.8%，204±138 U/L，p = 0.046）和LDH（+17%，3.3±0.88纳摩尔/分钟/毫升，p = 0.017）的个体峰值高于基线值，但ET-1（+9%，1.4±0.48皮克/毫升，p = 0.45）并非如此。运动后24小时（中位数4）和48小时（中位数4）报告有DOMS，肘屈肌的MVC从基线（216±44牛）在5分钟时降低（-34%，147±61牛，p < 0.001），24小时时降低（-17%，181±56牛，p = 0.005），48小时时降低（-9%，191±54牛，p = 0.003）。
离心手臂骑行引发EIMD，表现为MVC降低以及肌红蛋白、CK和LDH升高。
