通过抗分解代谢阻遏和细胞质小菌落突变抑制酿酒酵母中癌基因相关CDC基因的温度敏感突变。

Suppression of temperature sensitive mutations in oncogene-related CDC genes in Saccharomyces cerevisiae by catabolite repression resistance and cytoplasmic petite mutations.

作者信息

Egilsson V, Gudnason V, Jonasdottir A, Andresdottir V

机构信息

Laboratory of Cell Biology, University Hospital of Iceland, Reykjavik.

出版信息

Curr Genet. 1985;10(1):35-7. doi: 10.1007/BF00418491.

DOI:10.1007/BF00418491

PMID:3940063

Abstract

The "start" cell division control genes CDC36 and CDC28 have been reported to contain a certain sequence homology to tissue oncogenes (ets and some protein kinase encoding oncogenes respectively). Here we report that temperature sensitive mutations in these genes are suppressed in cytoplasmic "petite" mutants and catabolite repression resistant mutants.

摘要

据报道，“起始”细胞分裂控制基因CDC36和CDC28分别与组织癌基因（ets和一些编码蛋白激酶的癌基因）存在一定的序列同源性。在此我们报道，这些基因中的温度敏感突变在细胞质“小菌落”突变体和抗分解代谢物阻遏突变体中受到抑制。