口腔黏膜下纤维化中的肥大细胞密度：在发病机制中的可能作用。
Mast cell density in oral submucous fibrosis: a possible role in pathogenesis.
作者信息
Pujari Ravikumar, Vidya N
机构信息
Reader, Department Of Oral Pathology, Rajarajeshwari Dental College & Hospital, Bangalore.
出版信息
Int J Health Sci (Qassim). 2013 Jan;7(1):23-9. doi: 10.12816/0006017.
OBJECTIVE
Oral submucous fibrosis (OSMF) is a premalignant condition of oral cavity characterized by inflammation and progressive mucosal fibrosis. It has questionable pathogenesis. Mast cells (MC) have been associated with variety of inflammatory and fibrotic conditions, but little is known about their role in OSMF. Mast cells have been studied in normal gingiva, chronic inflammatory gingivitis, desquamative gingivitis, lichen planus, OSMF and oral cancer. Mast cells exhibit phenotypic plasticity. There is variation in the mast cell mediators with the change in the microenvironment, which makes the study of this cell in various diseases interesting.
STUDY DESIGN
A retrospective study was conducted to find possible correlation between MC in 25 cases of OSF, 10 cases of oral squamous cell carcinoma (OSCC) and 10 cases of normal buccal mucosa by means of acidified toluidine blue staining method.
RESULTS
The density of MC increased with disease progression. The densities of MC were significantly higher in OSMF than in normal buccal mucosa (p=0.001). The average numbers of MCs per square millimeter were 25, 49.50, 53.25 & 55.25 respectively.
CONCLUSION
The results suggest that MC have a definite role in initiation and progression of OSMF.
目的
口腔黏膜下纤维化（OSMF）是一种口腔癌前病变，其特征为炎症和进行性黏膜纤维化。其发病机制尚不明确。肥大细胞（MC）与多种炎症和纤维化疾病相关，但它们在OSMF中的作用鲜为人知。已对正常牙龈、慢性炎症性牙龈炎、剥脱性牙龈炎、扁平苔藓、OSMF和口腔癌中的肥大细胞进行了研究。肥大细胞表现出表型可塑性。随着微环境的变化，肥大细胞介质存在差异，这使得对该细胞在各种疾病中的研究变得有趣。
研究设计
采用酸化甲苯胺蓝染色法，对25例口腔黏膜下纤维性变（OSF）、10例口腔鳞状细胞癌（OSCC）和10例正常颊黏膜中的肥大细胞进行回顾性研究，以寻找可能的相关性。
结果
肥大细胞密度随疾病进展而增加。OSMF中肥大细胞的密度显著高于正常颊黏膜（p = 0.001）。每平方毫米肥大细胞的平均数量分别为25、49.50、53.25和55.25。
结论
结果表明肥大细胞在OSMF的发生和发展中具有一定作用。
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