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评估生物动力学成像对食管腺癌铂类化疗反应的可行性和预测准确性。

Evaluating the feasibility and predictive accuracy of biodynamic imaging to platinum-based chemotherapy response in esophageal adenocarcinoma.

作者信息

Ajrouch Ali, Krempley Ben, Karkash Ahmad, Dewitt John M, Al-Haddad Mohammad, Lim Dawith, Nolte David, Turek John, Perkins Susan M, Jalal Shadia I

机构信息

Division of Hematology Oncology, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, United States.

Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN, United States.

出版信息

Front Oncol. 2024 Sep 30;14:1429343. doi: 10.3389/fonc.2024.1429343. eCollection 2024.

DOI:10.3389/fonc.2024.1429343
PMID:39403334
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11471442/
Abstract

BACKGROUND

Esophageal cancer management lacks reliable response predictors to chemotherapy. In this study we evaluated the feasibility and accuracy of Biodynamic Imaging (BDI), a technology that employs digital holography as a rapid predictor of chemotherapy sensitivity in locoregional esophageal adenocarcinoma.

METHODS

Pre-treatment endoscopic pinch biopsies were collected from patients with esophageal adenocarcinoma during standard staging procedures. BDI analyzed the tumor samples and assessed chemotherapy sensitivity. BDI sensitivity predictions were compared to patients' pathological responses, the gold standard for determining clinical response, in the surgically treated subset (n=18).

RESULT

BDI was feasible with timely tissue acquisition, collection, and processing in all 30 enrolled patients and successful BDI analysis in 28/29 (96%) eligible. BDI accurately predicted chemotherapy response in 13/18 (72.2%) patients using a classifier for complete, marked, and partial/no-response. BDI technology had 100% negative predictive value for complete pathological response hence identifying patients unlikely to respond to treatment.

CONCLUSION

BDI technology can potentially predict patients' response to platinum chemotherapy. Additionally, this technology represents a promising step towards optimizing treatment strategies for esophageal adenocarcinoma patients by pre-emptively identifying non-responders to conventional platinum-based chemotherapy.

摘要

背景

食管癌的治疗缺乏可靠的化疗反应预测指标。在本研究中，我们评估了生物动力学成像（BDI）技术的可行性和准确性，该技术采用数字全息术作为局部区域食管腺癌化疗敏感性的快速预测指标。

方法

在标准分期程序中，从食管腺癌患者中采集治疗前的内镜钳取活检组织。BDI分析肿瘤样本并评估化疗敏感性。在接受手术治疗的亚组（n = 18）中，将BDI的敏感性预测结果与患者的病理反应（确定临床反应的金标准）进行比较。

结果

在所有30名入组患者中，BDI通过及时的组织采集、收集和处理是可行的，并且在28/29（96%）符合条件的患者中成功进行了BDI分析。使用针对完全缓解、显著缓解和部分/无缓解的分类器，BDI在13/18（72.2%）的患者中准确预测了化疗反应。BDI技术对完全病理缓解的阴性预测值为100%，因此能够识别出不太可能对治疗产生反应的患者。

结论

BDI技术有可能预测患者对铂类化疗的反应。此外，该技术通过预先识别对传统铂类化疗无反应者，朝着优化食管腺癌患者的治疗策略迈出了有希望的一步。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f697/11471442/3ae1a82ab780/fonc-14-1429343-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f697/11471442/356869e26b5e/fonc-14-1429343-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f697/11471442/17bc7c8f30f7/fonc-14-1429343-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f697/11471442/e2d24f39a156/fonc-14-1429343-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f697/11471442/2fc36b1cc5ac/fonc-14-1429343-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f697/11471442/3ae1a82ab780/fonc-14-1429343-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f697/11471442/356869e26b5e/fonc-14-1429343-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f697/11471442/17bc7c8f30f7/fonc-14-1429343-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f697/11471442/e2d24f39a156/fonc-14-1429343-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f697/11471442/2fc36b1cc5ac/fonc-14-1429343-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f697/11471442/3ae1a82ab780/fonc-14-1429343-g005.jpg

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