Shousha S, Backhous C M, Alaghband-Zadeh J, Burn I
Am J Clin Pathol. 1986 Jan;85(1):1-5. doi: 10.1093/ajcp/85.1.1.
During a study of the correlation between the histologic types of breast carcinoma and their hormone receptor contents, eight cases of the alveolar variant of invasive lobular carcinoma were identified, and all had estrogen receptor protein concentrations higher than 400 fmol/mg cytosol protein. Four more cases of the same variant were later prospectively diagnosed and their high estrogen receptor concentrations correctly predicted. All 12 tumors occurred in postmenopausal women. Most (92%) presented in Stage I or II of the disease. None of the patients died of the tumors during the short period of follow-up (median two years). It is concluded that the alveolar variant of lobular carcinoma of the breast is a tumor with consistently high estrogen receptor concentration and probably a low-grade malignancy. It is also suggested that the tumor may be the lobular equivalent of the ductal infiltrating Comedo carcinoma.
在一项关于乳腺癌组织学类型与其激素受体含量之间相关性的研究中，发现了8例浸润性小叶癌的腺泡变体病例，所有病例的雌激素受体蛋白浓度均高于400 fmol/mg胞浆蛋白。后来又前瞻性地诊断出另外4例相同变体病例，并正确预测了它们的高雌激素受体浓度。所有12例肿瘤均发生在绝经后妇女中。大多数（92%）处于疾病的I期或II期。在短时间随访（中位时间为两年）期间，没有患者死于肿瘤。结论是，乳腺小叶癌的腺泡变体是一种雌激素受体浓度持续较高且可能为低级别恶性肿瘤的肿瘤。还提出该肿瘤可能是导管浸润性粉刺癌的小叶对应物。
