Guberna Suzana Maria, Jercălău Cosmina Elena, Catană Andreea, Drăgan Eleonora, Avram Anamaria-Georgiana, Cuciureanu Irina, Manea Maria Mirabela, Andrei Cătălina Liliana
Department of Cardiology, Emergency Hospital "Bagdasar-Arseni", 050474 Bucharest, Romania.
Cardiology Department, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Healthcare (Basel). 2024 Sep 24;12(19):1909. doi: 10.3390/healthcare12191909.
Arterial stiffness is a crucial factor in the pathogenesis of cardiovascular disease, often associated with aging. However, the impact of smoking on arterial stiffness is frequently underestimated. This study aims to investigate the intricate relationship between smoking and arterial stiffness to advance our understanding of and therapeutic approaches to cardiovascular health.
A prospective analysis was conducted from January to July 2024, focusing on arterial stiffness parameters in a cohort of students from the Carol Davila University of Medicine and Pharmacy. Participants were categorized as smokers or non-smokers based on self-reported smoking status. The study endpoints included correlations between high pulse wave velocity, elevated peripheral and central systolic blood pressure, increased peripheral and central pulse pressure, and smoking status. These markers were assessed using an arteriograph device measuring the time difference between the initial forward pulse wave and the reflected pulse wave in the brachial artery to indirectly estimate the PWV using oscillometric pulsations.
Our investigation, involving 102 young individuals aged 20 to 26 (69 females, 33 males), revealed that smokers exhibited significantly higher average values of arterial stiffness indicators compared to non-smokers. Current smokers had higher mean systolic blood pressure (130.65 vs. 123.05 mmHg), higher mean peripheral pulse pressure (53.19 vs. 45.64 mmHg), higher mean central pulse pressure (33.66 vs. 29.69 mmHg), and higher mean pulse wave velocity (5.27 vs. 5.03 m/s).
The utilization of arterial stiffness markers as predictive tools offers opportunities for personalized treatment strategies, potentially enhancing cardiovascular health outcomes.
动脉僵硬度是心血管疾病发病机制中的一个关键因素，常与衰老相关。然而，吸烟对动脉僵硬度的影响常常被低估。本研究旨在探讨吸烟与动脉僵硬度之间的复杂关系，以增进我们对心血管健康的理解和治疗方法。
于2024年1月至7月进行了一项前瞻性分析，重点关注卡罗尔·戴维拉医药大学一组学生的动脉僵硬度参数。根据自我报告的吸烟状况，将参与者分为吸烟者或非吸烟者。研究终点包括高脉搏波速度、外周和中心收缩压升高、外周和中心脉压增加与吸烟状况之间的相关性。这些指标通过一种动脉造影设备进行评估，该设备测量肱动脉中初始正向脉搏波与反射脉搏波之间的时间差，以利用示波脉动间接估计脉搏波速度。
我们的调查涉及102名年龄在20至26岁之间的年轻人（69名女性，33名男性），结果显示吸烟者的动脉僵硬度指标平均值显著高于非吸烟者。当前吸烟者的平均收缩压更高（130.65对123.05 mmHg），平均外周脉压更高（53.19对45.64 mmHg），平均中心脉压更高（33.66对29.69 mmHg），平均脉搏波速度更高（5.27对5.03 m/s）。
将动脉僵硬度标志物用作预测工具为个性化治疗策略提供了机会，可能改善心血管健康结局。
