Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People's Republic of China.
Department of Rheumatology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People's Republic of China.
Gut Microbes. 2023 Dec;15(2):2290331. doi: 10.1080/19490976.2023.2290331. Epub 2023 Dec 10.
The global population is aging and age-related cardiovascular disease is increasing. Even after controlling for cardiovascular risk factors, readmission and mortality rates remain high. In recent years, more and more in-depth studies have found that the composition of the gut microbiota and its metabolites, such as trimethylamine N-oxide (TMAO), bile acids (BAs), and short-chain fatty acids (SCFAs), affect the occurrence and development of age-related cardiovascular diseases through a variety of molecular pathways, providing a new target for therapy. In this review, we discuss the relationship between the gut microbiota and age-related cardiovascular diseases, and propose that the gut microbiota could be a new therapeutic target for preventing and treating cardiovascular diseases.
全球人口正在老龄化，与年龄相关的心血管疾病也在增加。即使在控制了心血管危险因素后，再入院率和死亡率仍然很高。近年来，越来越多的深入研究发现，肠道微生物组及其代谢物（如三甲胺 N-氧化物（TMAO）、胆汁酸（BAs）和短链脂肪酸（SCFAs））的组成通过多种分子途径影响与年龄相关的心血管疾病的发生和发展，为治疗提供了新的靶点。在这篇综述中，我们讨论了肠道微生物组与与年龄相关的心血管疾病之间的关系，并提出肠道微生物组可能是预防和治疗心血管疾病的新治疗靶点。
