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银屑病患者与健康个体的皮肤微生物组比较分析——微生物失调的新见解：最终结果。

Comparative Analysis of the Cutaneous Microbiome in Psoriasis Patients and Healthy Individuals-Insights into Microbial Dysbiosis: Final Results.

机构信息

Department of Dermatology, "Saint Parascheva" Infectious Disease Clinical Hospital, 800179 Galati, Romania.

Department of Clinical Medical, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University, 800008 Galati, Romania.

出版信息

Int J Mol Sci. 2024 Oct 1;25(19):10583. doi: 10.3390/ijms251910583.

DOI:10.3390/ijms251910583
PMID:39408916
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11477231/
Abstract

Psoriasis is one of the most frequent chronic inflammatory skin diseases and exerts a significant psychological impact, causing stigmatization, low self-esteem and depression. The pathogenesis of psoriasis is remarkably complex, involving genetic, immune and environmental factors, some of which are still incompletely explored. The cutaneous microbiome has become more and more important in the pathogenesis of inflammatory skin diseases such as acne, rosacea, atopic dermatitis and psoriasis. Dysbiosis of the skin microbiome could be linked to acute flare ups in psoriatic disease, as recent studies suggest. Given this hypothesis, we conducted a study in which we evaluated the cutaneous microbiome of psoriasis patients and healthy individuals. In our study, we collected multiple samples using swab sampling, adhesive tape and punch biopsies. Our results are similar to other studies in which the qualitative and quantitative changes found in the cutaneous microbiome of psoriasis patients are different than healthy individuals. Larger, standardized studies are needed in order to elucidate the microbiome changes in psoriasis patients, clarify their role in the pathogenesis of psoriasis, decipher the interactions between the commensal microorganisms of the same and different niches and between microbiomes and the host and identify new therapeutic strategies.

摘要

银屑病是最常见的慢性炎症性皮肤病之一，对患者心理造成重大影响，导致其被歧视、自尊心下降和抑郁。银屑病的发病机制非常复杂，涉及遗传、免疫和环境因素，其中一些因素仍不完全清楚。皮肤微生物组在痤疮、酒渣鼻、特应性皮炎和银屑病等炎症性皮肤病的发病机制中变得越来越重要。最近的研究表明，皮肤微生物组的失调可能与银屑病的急性发作有关。基于这一假设，我们进行了一项研究，评估了银屑病患者和健康个体的皮肤微生物组。在我们的研究中，我们使用拭子采样、粘性胶带和打孔活检收集了多个样本。我们的结果与其他研究相似，发现银屑病患者皮肤微生物组的定性和定量变化与健康个体不同。需要进行更大规模、标准化的研究，以阐明银屑病患者的微生物组变化，阐明其在银屑病发病机制中的作用，解析同一和不同生态位共生微生物之间以及微生物组与宿主之间的相互作用，并确定新的治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8896/11477231/bbf99ae20c68/ijms-25-10583-g010.jpg
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