Applications of Platelet Concentrates (PCs) in Regenerative Onco-Urology: A Systematic Review of Literature.

: To assess the effectiveness of Platelet Concentrates (PCs) in the contest of Hemorrhagic, Actinic, and Radiation Cystitis, plus Urethral Obstruction or Stenosis. : Open article in English or Italian regarding in situ applications of PCs for the selected pathologies. : MEDLINE, Cochrane Library, and ELSEVIER. : High (and discussed). : Selection of relevant contents, resumed by digital tools, checked by authors and used throughout the manuscript. : 13 screened articles + 7 personal sources + 37 "extra" articles. : Pre-clinical and clinical studies demonstrated substantial symptom relief, mucosal restoration, and improved growth factor levels, reducing recurrence rates and complications. However, preparation protocols and results varied among studies. : Frequent low-quality studies with mall sample size, plus heterogeneous experimental setups and nomenclature/preparations. : PCs demonstrate promise due to their bioactive components, enhancing tissue repair and reducing inflammation with no significant adverse events. Despite positive outcomes in pre-clinical and clinical studies, variability in preparation protocols and small sample sizes, together with inconsistent results, highlight the need for high-quality research to validate PCs' clinical efficacy and cost-effectiveness.