Sherman A H, Amoore J E, Weigel V
Otolaryngol Head Neck Surg (1979). 1979 Nov-Dec;87(6):717-33. doi: 10.1177/019459987908700604.
Serial dilutions of pyridine in water are employed for measuring the olfactory detection thresholds of patients. Experimental precautions are described that improve the precision and accuracy of the method. Existing data on the sensitivities of hyposmic patients are confirmed, but the sensitivities of normal subjects and of hyperosmic patients are believed to have been substantially overestimated in some earlier publications. Routine clinical applications of the revised pyridine odor threshold test are discussed. In the author's experience, the average cystic fibrosis patient is slightly hyposmic, and some cases of pituitary tumor are accompanied by a 100,000-fold hyperosmia.
通过使用吡啶在水中的系列稀释液来测量患者的嗅觉检测阈值。文中描述了一些实验预防措施，这些措施提高了该方法的精密度和准确性。已有的嗅觉减退患者敏感性数据得到了证实，但正常受试者和嗅觉过敏患者的敏感性在一些早期出版物中被认为被大幅高估了。文中还讨论了修订后的吡啶气味阈值测试的常规临床应用。根据作者的经验，平均而言，囊性纤维化患者有轻微的嗅觉减退，而一些垂体瘤病例伴有高达10万倍的嗅觉过敏。
