The Second Affiliated Hospital of Fujian, University of Traditional Chinese Medicine, Fuzhou, 350003, China.
Department of Cardiology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200000, China.
J Health Popul Nutr. 2024 Oct 16;43(1):163. doi: 10.1186/s41043-024-00660-x.
Although abnormal lipid metabolism is one of the major risk factors for diabetes, the correlation between lipids and glucose is rarely discussed in the general population. The differences in lipid-glucose correlations across gender and ethnicity have been even more rarely studied. We examined the association between fasting blood glucose (FBG) and lipids, including triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and apolipoprotein B (ApoB), using 6,093 participants aged 20 years or older from the National Health and Nutrition Examination Survey (NHANES).
Analyses were performed using multiple logistic regression and generalised additive models.
When other confounders were considered, we found that fasting glucose was positively correlated with triglycerides and negatively correlated with HDL-C, whereas total cholesterol, LDL-C cholesterol, and fasting glucose were related to each other in a U-curve fashion, with inflection points of 5.17 mmol/L and 2.3 mmol/L, respectively.This relationship persisted in subgroups of different sexes and races. A positive correlation was found between fasting glucose and ApoB, but subgroup analyses revealed that this relationship was not correlated across gender and race.
In the general population, fasting blood glucose levels were positively correlated with TG, negatively correlated with HDL-C, and U-shaped with total cholesterol and LDL-C. The likelihood of developing diabetes was 40% higher when LDL-C was greater than 2.3 mmol/L than in patients with LDL-C less than 2.3 mmol/L.
尽管脂代谢异常是糖尿病的主要危险因素之一，但在普通人群中很少讨论脂质与血糖之间的关系。性别和种族之间的血脂-血糖相关性差异研究则更为少见。我们使用 6093 名年龄在 20 岁及以上的来自国家健康和营养检查调查（NHANES）的数据，研究了空腹血糖（FBG）与血脂（包括甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）和载脂蛋白 B（ApoB）之间的关系。
使用多元逻辑回归和广义加性模型进行分析。
当考虑其他混杂因素时，我们发现空腹血糖与甘油三酯呈正相关，与 HDL-C 呈负相关，而总胆固醇、LDL-C 胆固醇与空腹血糖之间呈 U 型关系，拐点分别为 5.17mmol/L 和 2.3mmol/L。这种关系在不同性别和种族的亚组中仍然存在。空腹血糖与 ApoB 呈正相关，但亚组分析显示这种关系在性别和种族之间没有相关性。
在普通人群中，空腹血糖水平与 TG 呈正相关，与 HDL-C 呈负相关，与总胆固醇和 LDL-C 呈 U 型关系。当 LDL-C 大于 2.3mmol/L 时，发生糖尿病的可能性比 LDL-C 小于 2.3mmol/L 的患者高 40%。
