Bettinotti Branco G M, Tegegn Mickias B, Razuk Victor, Bailey Som, Hann Rowena, Mendoza Cesar, Calfa Marian T, Colombo Rosario A
Department of Internal Medicine, Mount Sinai Medical Center, 4300 Alton Rd, Miami, FL 33140, United States.
Department of Medicine, University of Miami Miller School of Medicine, 1600 NW 10th Ave, Miami, FL 33136, United States.
Oxf Med Case Reports. 2024 Oct 15;2024(10):omae120. doi: 10.1093/omcr/omae120. eCollection 2024 Oct.
Spontaneous coronary artery dissection (SCAD) is an important cause of acute coronary syndrome among young women, especially in the postpartum period. Pregnancy-Associated SCAD (P-SCAD), an aggressive subtype, frequently involves multi-vessel dissection, decreased left ventricular function, and higher mortality. Here we present a rare case of postpartum pre-eclampsia complicated by multi-vessel SCAD in a 40-year-old multiparous Haitian black woman. Diagnosis was established with coronary angiography which revealed spontaneous dissection of the left anterior descendant, left circumflex, and right coronary arteries. Given the patient remained hemodynamically stable no percutaneous coronary intervention was indicated. She experienced recurrent anginal symptoms during her hospitalization that were managed with the addition of clopidogrel. The pathophysiology of P-SCAD is not well understood and thought to be related to an increased state of hemodynamic stress and hormonal fluctuation. The role of pre-eclampsia as a risk factor remains poorly defined and warrants further investigation.
自发性冠状动脉夹层(SCAD)是年轻女性急性冠状动脉综合征的重要病因,尤其是在产后阶段。妊娠相关SCAD(P-SCAD)是一种侵袭性亚型,常累及多支血管夹层、左心室功能下降及死亡率较高。在此,我们报告一例罕见病例,一名40岁多产的海地黑人女性产后子痫前期并发多支血管SCAD。通过冠状动脉造影确诊,显示左前降支、左旋支和右冠状动脉自发性夹层。鉴于患者血流动力学保持稳定,未行经皮冠状动脉介入治疗。她在住院期间出现复发性心绞痛症状,加用氯吡格雷进行处理。P-SCAD的病理生理学尚未完全明确,被认为与血流动力学应激增加和激素波动状态有关。子痫前期作为危险因素的作用仍不明确,值得进一步研究。