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低收入和中等收入国家所有女性全球人乳头瘤病毒疫苗接种指南;创新与公平的简要综述

A guide to global access to HPV vaccination to all women in low- and middle-income countries; a minireview of innovation and equity.

作者信息

Ewongwo Agnes, Sahor Aji Fatou, Ngwa Wilfred, Nwachukwu Chika

机构信息

Department of Radiation Oncology, Stanford University, Palo Alto, CA, United States.

Department of Obstetrics and Gynecology, University of Texas Health, Houston, TX, United States.

出版信息

Front Oncol. 2024 Oct 2;14:1380663. doi: 10.3389/fonc.2024.1380663. eCollection 2024.

Abstract

INTRODUCTION

Cervical cancer is caused by the human papillomavirus (HV), and accounts for more than 311,000 preventable deaths annually, with 85% occurring in low-and middle-income countries. Despite being preventable through screening and screening, significant barriers to implementing HPV vaccination persist in developing nations. This review study aims to identify these barriers and propose innovative, evidence-based solutions to improve vaccination rates and reduce cervical cancer mortality.

METHODS

A systematic review search was conducted using PubMed, Embase, and Cochrane Database of Systemic Reviews. Keywords related to HPV vaccination barriers and implementation strategies in developing countries were used. Relevant demonstration projects, pilot studies, and evidence-based research articles were reviewed.

RESULTS

Identifiable barriers to a successful vaccine implementation program in a developing country include vaccine costs, societal, cultural resistance, misinformation, logistical challenges in vaccine delivery, and inadequate human resources. Solutions to these barriers include a subsidized vaccine pricing, community sensitization, education and well-trained media professionals to dispel misinformation, and partnerships with both public and private sector for efficient vaccine distribution.

DISCUSSION

These findings highlight critical barriers that impede HPV vaccination efforts in developing countries and offers practical solutions to overcome these challenges. This aggregate of data can help inform future developing countries' implementation programs to further the World Health Assembly mission to vaccinate 90% of eligible girls globally by 2030.

摘要

引言

宫颈癌由人乳头瘤病毒(HPV)引起,每年导致超过31.1万例可预防的死亡,其中85%发生在低收入和中等收入国家。尽管可通过筛查预防,但在发展中国家,实施HPV疫苗接种仍存在重大障碍。本综述研究旨在识别这些障碍,并提出创新的、基于证据的解决方案,以提高疫苗接种率并降低宫颈癌死亡率。

方法

使用PubMed、Embase和Cochrane系统评价数据库进行系统综述检索。使用了与发展中国家HPV疫苗接种障碍和实施策略相关的关键词。对相关示范项目、试点研究和基于证据的研究文章进行了综述。

结果

在发展中国家,成功实施疫苗接种计划的可识别障碍包括疫苗成本、社会和文化阻力、错误信息、疫苗配送中的后勤挑战以及人力资源不足。这些障碍的解决方案包括补贴疫苗定价、社区宣传、教育以及训练有素的媒体专业人员以消除错误信息,以及与公共和私营部门建立伙伴关系以实现高效的疫苗分发。

讨论

这些发现突出了阻碍发展中国家HPV疫苗接种工作的关键障碍,并提供了克服这些挑战的实际解决方案。这些汇总数据有助于为未来发展中国家的实施计划提供参考,以推动世界卫生大会到2030年为全球90%符合条件的女孩接种疫苗的使命。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3259/11480722/5d4846e8b622/fonc-14-1380663-g001.jpg

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