Faculty of Physical Chemistry, University of Belgrade, 12-16 Studentski Trg Street, Belgrade, 11000, Serbia.
Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
J Headache Pain. 2024 Oct 17;25(1):182. doi: 10.1186/s10194-024-01888-y.
This study investigated for a possible contributing role of hippocampus in the different clinical phenotypic manifestations of migraine aura.
Herein, patients were categorized as those with pure visual aura (MwAv), those who reported additional somatosensory and dysphasic symptoms (MwAvsd), and healthy controls (HCs). Neuroimaging data obtained using FreeSurfer-based segmentation of hippocampal subfields were compared between HCs and patients with migraine with aura, as well as between HCs and those with MwAv and MwAvsd. The average migraine aura complexity score (MACS) was calculated for each patient to investigate the correlation between hippocampal subfield volume and migraine aura complexity.
Herein, 46 patients with migraine with aura (28 MwAvsd and 18 MwAv) and 31 HCs were included. There were no significant differences in the hippocampal subfields between HCs and patients with migraine with aura. The average MACS negatively correlated with the volumes of the left and right hippocampi, Cornu Ammonis (CA) 1, CA3, CA4, molecular layer, left granule cell layer of the dentate gyrus, hippocampal fissure, and hippocampus-amygdala transition area. The MwAvsd subgroup had significantly smaller whole hippocampal volumes in both hemispheres, as well as in both subicula, compared with the MwAv subgroup and HCs. In addition, the left molecular layer, right CA1, and hippocampal fissures were significantly smaller in the MwAvsd group than in the MwAv subgroup and HCs.
Smaller left and right hippocampal volumes, particularly of the subiculum/CA1 area, may play an important role in the pathophysiology of somatosensory and dysphasic symptoms in migraine with aura.
本研究旨在探讨海马在偏头痛先兆不同临床表型中的可能作用。
在此，将患者分为单纯视觉先兆偏头痛（MwAv）组、报告有其他感觉和言语障碍症状的偏头痛先兆（MwAvsd）组和健康对照组（HCs）。使用基于 FreeSurfer 的海马亚区分割方法比较 HCs 与偏头痛先兆患者、HCs 与 MwAv 组和 MwAvsd 组之间的神经影像学数据。计算每位患者的平均偏头痛先兆复杂性评分（MACS），以探讨海马亚区体积与偏头痛先兆复杂性之间的相关性。
在此，纳入了 46 例偏头痛先兆患者（28 例 MwAvsd 和 18 例 MwAv）和 31 例 HCs。HCs 和偏头痛先兆患者之间的海马亚区无显著差异。平均 MACS 与左右海马、CA1、CA3、CA4、分子层、左齿状回颗粒细胞层、海马裂和海马杏仁核过渡区的体积呈负相关。与 MwAv 组和 HCs 相比，MwAvsd 亚组双侧海马的总体积以及双侧下托和海马旁回的体积明显较小。此外，与 MwAv 组和 HCs 相比，MwAvsd 组左侧分子层、右侧 CA1 和海马裂明显较小。
左右海马体积较小，特别是下托/CA1 区域，可能在偏头痛先兆的感觉和言语障碍症状的病理生理学中起重要作用。
