Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Immunol. 2024 Mar 13;15:1379490. doi: 10.3389/fimmu.2024.1379490. eCollection 2024.
Fibroblasts are an important subset of mesenchymal cells in maintaining skin homeostasis and resisting harmful stimuli. Meanwhile, fibroblasts modulate immune cell function by secreting cytokines, thereby implicating their involvement in various dermatological conditions such as psoriasis, vitiligo, and atopic dermatitis. Recently, variations in the subtypes of fibroblasts and their expression profiles have been identified in these prevalent autoimmune skin diseases, implying that fibroblasts may exhibit distinct functionalities across different diseases. In this review, from the perspective of their fundamental functions and remarkable heterogeneity, we have comprehensively collected evidence on the role of fibroblasts and their distinct subpopulations in psoriasis, vitiligo, atopic dermatitis, and scleroderma. Importantly, these findings hold promise for guiding future research directions and identifying novel therapeutic targets for treating these diseases.
成纤维细胞是维持皮肤内稳态和抵抗有害刺激的间充质细胞的重要亚群。同时，成纤维细胞通过分泌细胞因子来调节免疫细胞的功能，从而暗示它们参与各种皮肤疾病，如银屑病、白癜风和特应性皮炎。最近，在这些常见的自身免疫性皮肤病中，已经确定了成纤维细胞亚型及其表达谱的变化，这意味着成纤维细胞在不同疾病中可能表现出不同的功能。在这篇综述中，我们从它们的基本功能和显著异质性的角度，全面收集了成纤维细胞及其在银屑病、白癜风、特应性皮炎和硬皮病中的不同亚群的作用的证据。重要的是，这些发现为指导未来的研究方向和确定治疗这些疾病的新的治疗靶点提供了希望。
