Xiao Kunhong, Chen Ruiye, Lin Rong, Hu Wenyi, Liu Jiahao, Yusufu Mayinuer, Huang Yan, Li Li
Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China.
Department of Ophthalmology and Optometry, Fujian Medical University, Fuzhou, China.
Front Nutr. 2024 Oct 3;11:1477403. doi: 10.3389/fnut.2024.1477403. eCollection 2024.
To investigate the associations between circulating micronutrients (vitamins A, C, D, E, and carotenoids) and the risk of myopia.
A total of 1,620 adolescents from the 2003-2006 National Health and Nutrition Examination Survey (NHANES) were included. Logistic regression was used to analyze the associations of micronutrients with myopia and high myopia. Restricted cubic spline analysis was employed to assess the potential nonlinear relationships.
Among the 1,620 adolescents, 549 were diagnosed with myopia. After adjusting for multiple covariates, only cis--carotene was significantly associated with the risk of myopia (OR 1.19, 95% CI 1.03-1.39) and high myopia (OR 1.44, 95% CI 1.03-2.03). No significant associations were found between vitamins A, D, E, C, -carotene, trans--carotene, lutein zeaxanthin, and myopia. No nonlinear relationships were observed between any of the micronutrients and myopia.
Cis-β-carotene is significantly associated with an increased risk of myopia and high myopia. Further research is needed to understand the underlying mechanisms and potential impact of cis--carotene on ocular health.
探讨循环中的微量营养素（维生素A、C、D、E和类胡萝卜素）与近视风险之间的关联。
纳入了2003 - 2006年美国国家健康与营养检查调查（NHANES）中的1620名青少年。采用逻辑回归分析微量营养素与近视和高度近视之间的关联。使用受限立方样条分析来评估潜在的非线性关系。
在这1620名青少年中，549人被诊断为近视。在调整多个协变量后，仅顺式 - 胡萝卜素与近视风险（比值比1.19，95%置信区间1.03 - 1.39）和高度近视风险（比值比1.44，95%置信区间1.03 - 2.03）显著相关。未发现维生素A、D、E、C、α - 胡萝卜素、反式 - 胡萝卜素、叶黄素玉米黄质与近视之间存在显著关联。未观察到任何微量营养素与近视之间存在非线性关系。
顺式β - 胡萝卜素与近视和高度近视风险增加显著相关。需要进一步研究以了解顺式 - 胡萝卜素对眼部健康的潜在机制和影响。
