Liu Xiaohui, Shen Hong, Chen Mingfeng, Shao Jun
Department of Ultrasound Diagnosis, The First People's Hospital of Kunshan, Kunshan Hospital Affiliated to Jiangsu University, Kunshan, China.
Front Nutr. 2021 Nov 11;8:760985. doi: 10.3389/fnut.2021.760985. eCollection 2021.
Vitamins and carotenoids may be involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Previously related publications mainly focused on vitamin D and vitamin E, and studies on other vitamins and carotenoids and NAFLD are scarce. This study aimed to explore the clinical relevance of vitamin A, B vitamins (vitamin B1, vitamin B2, niacin, vitamin B6, folate, vitamin B12, and choline), vitamin C and carotenoids (α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein + zeaxanthin) with liver steatosis and fibrosis in the 2017-2018 NHANES ( = 4,352). Liver steatosis and fibrosis were detected by transient elastography. Logistic regression, linear regression and restricted cubic splines were adopted to explore the non-linear dose-response relationships. Higher intakes of vitamin C [0.68 (0.50-0.93)] and β-carotene [0.71 (0.54-0.93)] were inversely associated with liver steatosis. Higher levels of serum vitamin C [0.45 (0.32-0.62)] were inversely associated with liver fibrosis, while higher intakes of choline [1.43 (1.04-1.98)] and α-carotene [1.67 (1.01-2.74)] were positively associated with liver fibrosis. In addition, marginally inverse association between lutein + zeaxanthin and liver steatosis and positive association between vitamin B12 and liver fibrosis were found. In linear regression, the above-mentioned associations between vitamin C, β-carotene, and lutein + zeaxanthin and liver steatosis, and serum vitamin C, choline, α-carotene, and vitamin B12 and liver fibrosis were also found. The above-mentioned associations were mainly linear, while the relationship between β-carotene and liver steatosis might be non-linear. Vitamin C, α-carotene, β-carotene, lutein + zeaxanthin, choline and vitamin B12 may be associated with liver steatosis and fibrosis.
维生素和类胡萝卜素可能参与非酒精性脂肪性肝病（NAFLD）的发病机制。此前相关出版物主要聚焦于维生素D和维生素E，而关于其他维生素、类胡萝卜素与NAFLD的研究较少。本研究旨在探讨2017 - 2018年美国国家健康与营养检查调查（NHANES，n = 4352）中维生素A、B族维生素（维生素B1、维生素B2、烟酸、维生素B6、叶酸、维生素B12和胆碱）、维生素C和类胡萝卜素（α - 胡萝卜素、β - 胡萝卜素、β - 隐黄质、番茄红素、叶黄素 + 玉米黄质）与肝脏脂肪变性和纤维化的临床相关性。通过瞬时弹性成像检测肝脏脂肪变性和纤维化。采用逻辑回归、线性回归和受限立方样条来探索非线性剂量反应关系。较高的维生素C摄入量[0.68（0.50 - 0.93）]和β - 胡萝卜素摄入量[0.71（0.54 - 0.93）]与肝脏脂肪变性呈负相关。较高的血清维生素C水平[0.45（0.32 - 0.62）]与肝脏纤维化呈负相关，而较高的胆碱摄入量[1.43（1.04 - 1.98）]和α - 胡萝卜素摄入量[1.67（1.01 - 2.74）]与肝脏纤维化呈正相关。此外，发现叶黄素 + 玉米黄质与肝脏脂肪变性之间存在微弱的负相关，维生素B12与肝脏纤维化之间存在正相关。在线性回归中，也发现了维生素C、β - 胡萝卜素、叶黄素 + 玉米黄质与肝脏脂肪变性，以及血清维生素C、胆碱、α - 胡萝卜素和维生素B12与肝脏纤维化之间的上述关联。上述关联主要为线性，而β - 胡萝卜素与肝脏脂肪变性之间的关系可能是非线性的。维生素C、α - 胡萝卜素、β - 胡萝卜素、叶黄素 + 玉米黄质、胆碱和维生素B12可能与肝脏脂肪变性和纤维化有关。
