Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Mol Cell. 2024 Oct 17;84(20):3861-3862. doi: 10.1016/j.molcel.2024.09.028.
In this issue, Sinha et al. use cellular chromatin reporter assays along with CRISPR gene editing to reveal that the histone H3.3K36M oncohistone mutation disrupts epigenetic memory and stability of H3K9me3 domains by blocking transitions into a stably repressed state.
在本期中，Sinha 等人使用细胞染色质报告分析，以及 CRISPR 基因编辑，揭示了组蛋白 H3.3K36M 癌化组蛋白突变通过阻止向稳定的抑制状态转变，破坏了 H3K9me3 结构域的表观遗传记忆和稳定性。
