Reibelt Antonia, Quandt Fanny, Schulz Robert
Experimental Electrophysiology and Neuroimaging Lab, Department of Neurology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany.
Brain Commun. 2023 Sep 28;5(5):fcad250. doi: 10.1093/braincomms/fcad250. eCollection 2023.
Brain imaging and electrophysiology have significantly enhanced our current understanding of stroke-related changes in brain structure and function and their implications for recovery processes. In the motor domain, most studies have focused on key motor areas of the frontal lobe including the primary and secondary motor cortices. Time- and recovery-dependent alterations in regional anatomy, brain activity and inter-regional connectivity have been related to recovery. In contrast, the involvement of posterior parietal cortical areas in stroke recovery is poorly understood although these regions are similarly important for important aspects of motor functioning in the healthy brain. Just in recent years, the field has increasingly started to explore to what extent posterior parietal cortical areas might undergo equivalent changes in task-related activation, regional brain structure and inter-regional functional and structural connectivity after stroke. The aim of this scoping review is to give an update on available data covering these aspects and thereby providing novel insights into parieto-frontal interactions for systems neuroscience stroke recovery research in the upper limb motor domain.
脑成像和电生理学显著增进了我们目前对中风相关的脑结构和功能变化及其对恢复过程影响的理解。在运动领域，大多数研究集中于额叶的关键运动区域，包括初级和次级运动皮层。区域解剖结构、脑活动和区域间连接的时间依赖性和恢复依赖性改变与恢复相关。相比之下，尽管后顶叶皮层区域对健康大脑运动功能的重要方面同样重要，但对其在中风恢复中的作用了解甚少。就在近年来，该领域越来越多地开始探索中风后后顶叶皮层区域在任务相关激活、区域脑结构以及区域间功能和结构连接方面可能发生同等变化的程度。本范围综述的目的是更新涵盖这些方面的现有数据，从而为上肢运动领域系统神经科学中风恢复研究中的顶叶-额叶相互作用提供新的见解。
