Department of Translational Medicine, Queen's University, 18 Stuart Street, Room 230, Botterell Hall, Kingston, Ontario, K7L 3N6, Canada.
Centre of Neuroscience Studies, Queen's University, Kingston, Ontario, K7L 3N6, Canada.
Transl Stroke Res. 2024 Feb;15(1):127-139. doi: 10.1007/s12975-022-01115-3. Epub 2022 Dec 21.
Stroke is a devastating disease that results in neurological deficits and represents a leading cause of death and disability worldwide. Following a stroke, there is a degree of spontaneous recovery of function, the neural basis of which is of great interest among clinicians in their efforts to reduce disability following stroke and enhance rehabilitation. Conventionally, work on spontaneous recovery has tended to focus on the neural reorganization of motor cortical regions, with comparably little attention being paid to changes in non-motor regions and how these relate to recovery. Here we show, using structural neuroimaging in a macaque stroke model (N = 31) and by exploiting individual differences in spontaneous behavioural recovery, that the preservation of regions in the parietal and temporal cortices predict animal recovery. To characterize recovery, we performed a clustering analysis using Non-Human Primate Stroke Scale (NHPSS) scores and identified a good versus poor recovery group. By comparing the preservation of brain volumes in the two groups, we found that brain areas in integrity of brain areas in parietal, temporal and somatosensory cortex were associated with better recovery. In addition, a decoding approach performed across all subjects revealed that the preservation of specific brain regions in the parietal, somatosensory and medial frontal cortex predicted recovery. Together, these findings highlight the importance of parietal and temporal regions in spontaneous behavioural recovery.
中风是一种破坏性疾病，会导致神经功能缺损，是全球范围内导致死亡和残疾的主要原因。中风后会有一定程度的功能自发恢复，其神经基础是临床医生关注的焦点，他们努力减少中风后的残疾并促进康复。传统上，自发恢复的研究工作往往集中在运动皮层区域的神经重组上，而对非运动区域的变化及其与恢复的关系关注较少。在这里，我们使用猕猴中风模型的结构神经影像学（N=31），并利用自发行为恢复的个体差异，表明顶叶和颞叶皮层区域的保留可以预测动物的恢复情况。为了描述恢复情况，我们使用非人类灵长类动物中风量表（NHPSS）评分进行聚类分析，并确定了恢复良好和恢复不良的组。通过比较两组大脑体积的保留情况，我们发现顶叶、颞叶和体感皮层的完整脑区与更好的恢复相关。此外，在所有受试者中进行的解码方法表明，顶叶、体感和内侧额皮质中特定脑区的保留可以预测恢复。总之，这些发现强调了顶叶和颞叶区域在自发行为恢复中的重要性。
