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皮肤转移:胰腺腺癌的罕见表现

Cutaneous Metastasis: A Rare Presentation of Pancreatic Adenocarcinoma.

作者信息

Nichkaode Prabhat, Dwivedi Divyansh

机构信息

Department of General Surgery, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pune, IND.

出版信息

Cureus. 2024 Sep 19;16(9):e69767. doi: 10.7759/cureus.69767. eCollection 2024 Sep.

Abstract

Pancreatic adenocarcinomas are highly malignant tumors. The liver, peritoneum, and, very rarely, the skin are the sites of pancreatic metastases. Cutaneous metastasis is rare, with scalp metastasis being seldomly found. We report the case of an elderly woman who initially presented with ulcerated scalp swellings. The immunohistochemistry analysis of the swollen scalp confirmed the presence of a far-metastasized adenocarcinoma. Imaging of the abdomen performed due to increasing cholestatic jaundice revealed adenocarcinoma located at the head of the pancreas. Cholestatic jaundice was treated by trans-biliary percutaneous drainage. She is currently on a chemotherapy regimen. The patient had a follow-up appointment one month ago for the fourth cycle of gemcitabine and paclitaxel and will continue to follow up until eight cycles of chemotherapy sessions. Cutaneous metastases resulting from pancreatic cancer are a rare occurrence and may occasionally present as the only visible symptom; therefore, they should be included in the differential diagnosis of skin lesions.

摘要

胰腺腺癌是高度恶性肿瘤。肝脏、腹膜,极少数情况下皮肤是胰腺转移的部位。皮肤转移罕见,头皮转移更是鲜有发现。我们报告一例老年女性病例,最初表现为头皮溃疡性肿胀。对肿胀头皮进行免疫组化分析证实存在远处转移性腺癌。因胆汁淤积性黄疸加重而进行的腹部影像学检查显示胰腺癌位于胰头。胆汁淤积性黄疸通过经皮经肝胆道引流治疗。她目前正在接受化疗方案。患者一个月前进行了吉西他滨和紫杉醇第四周期的随访预约,并将继续随访直至完成八个周期的化疗疗程。胰腺癌导致的皮肤转移罕见,偶尔可能表现为唯一可见症状;因此,应将其纳入皮肤病变的鉴别诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a348/11491125/5dfd606fc641/cureus-0016-00000069767-i01.jpg

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