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环境肿瘤学的现状与展望

Current status and perspectives in environmental oncology.

作者信息

Liu Jie, Gan Ting, Hu Wenbiao, Li Yumin

机构信息

Department of Tumor Surgery, General Surgery, Gansu Provincial Key Laboratory of Gastrointestinal Tumor, Key Laboratory of Environmental Oncology in Gansu Province Lanzhou University Second Hospital Lanzhou Gansu China.

Center for Digestive System Tumor Transformation and Innovation Engineering, Environmental Oncology Center Lanzhou University Lanzhou Gansu China.

出版信息

Chronic Dis Transl Med. 2024 Aug 27;10(4):293-301. doi: 10.1002/cdt3.148. eCollection 2024 Dec.

Abstract

Cancer stands as a leading global cause of death, with its etiology characterized by complexity and multifaceted factors. Growing research indicates a strong correlation between environmental factors and cancer incidence, underscoring the critical importance of intervening in environmental risk factors to mitigate cancer occurrence. Despite this, specialized research institutions focusing on the intersection of environment and cancer remain scarce, with global investment in cancer prevention significantly trailing behind efforts in diagnosis and treatment. Against the backdrop of rapid global climate change, industrialization, urbanization, aging populations, and the globalization of lifestyles, we proposed the concept of (EO) to address these challenges. We discussed the rationale and necessity of developing EO and presented a comprehensive research framework focusing on cancer prevention and treatment. Future EO research will aim to identify cancer causes and implement early prevention strategies using advanced scientific technologies and methods. By emphasizing multidisciplinary collaboration and integrating molecular biology at the micro level, EO will explore the relationship between external and internal environments and cancer. EO will identify potential therapeutic targets by studying the pathways through which environmental exposures lead to carcinogenesis. EO will develop early warning systems and disseminate research findings by collecting big data, employing robust statistical models, and establishing research centers.

摘要

癌症是全球主要的死因之一,其病因复杂且涉及多方面因素。越来越多的研究表明环境因素与癌症发病率之间存在密切关联,这凸显了干预环境风险因素以降低癌症发生的至关重要性。尽管如此,专注于环境与癌症交叉领域的专业研究机构仍然稀缺,全球在癌症预防方面的投资明显落后于诊断和治疗方面的努力。在全球气候变化迅速、工业化、城市化、人口老龄化以及生活方式全球化的背景下,我们提出了环境肿瘤学(EO)的概念来应对这些挑战。我们讨论了发展环境肿瘤学的基本原理和必要性,并提出了一个专注于癌症预防和治疗的综合研究框架。未来的环境肿瘤学研究旨在利用先进的科学技术和方法确定癌症病因并实施早期预防策略。通过强调多学科合作并在微观层面整合分子生物学,环境肿瘤学将探索外部和内部环境与癌症之间的关系。环境肿瘤学将通过研究环境暴露导致致癌的途径来确定潜在的治疗靶点。环境肿瘤学将通过收集大数据、采用强大的统计模型并建立研究中心来开发预警系统并传播研究结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d49c/11483686/ab3ea05be8c2/CDT3-10-293-g002.jpg

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