Division of Medicine, University College London, University of London, London, United Kingdom.
The Institute of Dental Sciences, Hebrew University, Jerusalem, Israel.
Front Immunol. 2019 Nov 7;10:2581. doi: 10.3389/fimmu.2019.02581. eCollection 2019.
Blood monocytes develop in the bone marrow before being released into the peripheral circulation. The circulating monocyte pool is composed of multiple subsets, each with specialized functions. These cells are recruited to repopulate resident monocyte-derived cells in the periphery and also to sites of injury. Several extrinsic factors influence the function and quantity of monocytes in the blood. Here, we outline the impact of sex, ethnicity, age, sleep, diet, and exercise on monocyte subsets and their function, highlighting that steady state is not a single physiological condition. A clearer understanding of the relationship between these factors and the immune system may allow for improved therapeutic strategies.
血液单核细胞在骨髓中发育成熟后，会被释放到外周循环中。循环单核细胞池由多个亚群组成，每个亚群都具有专门的功能。这些细胞被招募来重新填充外周组织中常驻的单核细胞来源细胞，并迁移到损伤部位。许多外在因素会影响血液中单核细胞的功能和数量。在这里，我们概述了性别、种族、年龄、睡眠、饮食和运动对单核细胞亚群及其功能的影响，强调了稳态不是单一的生理状态。更清楚地了解这些因素与免疫系统之间的关系，可能有助于制定更好的治疗策略。
