富含硝酸盐的甜菜根汁对患有常染色体显性多囊肾病的高血压成年人血压影响的随机试验 - Suppr

Randomized Trial of Nitrate-Replete Beetroot Juice on Blood Pressure in Hypertensive Adults with ADPKD.

作者信息

Sagar Priyanka S, Elhindi James, Chau Katrina, Harris David C, Lee Vincent, Sud Kamal, Wong Nikki, Rangan Gopala K

机构信息

Michael Stern Laboratory for Polycystic Kidney Disease, Westmead Institute for Medical Research, The University of Sydney, Sydney, Australia.

Department of Renal Medicine, Westmead Hospital, Western Sydney Local Health District, Sydney, Australia.

出版信息

Kidney Int Rep. 2024 Jul 24;9(10):3045-3048. doi: 10.1016/j.ekir.2024.07.017. eCollection 2024 Oct.

DOI:10.1016/j.ekir.2024.07.017

PMID:39430189

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11489447/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f56/11489447/649ac4e71e91/gr1.jpg

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Randomized Trial of Nitrate-Replete Beetroot Juice on Blood Pressure in Hypertensive Adults with ADPKD.富含硝酸盐的甜菜根汁对患有常染色体显性多囊肾病的高血压成年人血压影响的随机试验

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Efficacy of beetroot juice on reducing blood pressure in hypertensive adults with autosomal dominant polycystic kidney disease (BEET-PKD): study protocol for a double-blind, randomised, placebo-controlled trial.甜菜根汁降低常染色体显性遗传多囊肾病（BEET-PKD）高血压成人血压的疗效：一项双盲、随机、安慰剂对照试验的研究方案。

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Absence of an effect of high nitrate intake from beetroot juice on blood pressure in treated hypertensive individuals: a randomized controlled trial.甜菜根汁中高硝酸盐摄入量对接受治疗的高血压患者血压无影响：一项随机对照试验。

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Effects of dietary nitrate supplementation, from beetroot juice, on blood pressure in hypertensive pregnant women: A randomised, double-blind, placebo-controlled feasibility trial.膳食硝酸盐补充剂（甜菜根汁）对高血压孕妇血压的影响：一项随机、双盲、安慰剂对照的可行性试验。

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Acute Effects of Nitrate-Rich Beetroot Juice on Blood Pressure, Hemostasis and Vascular Inflammation Markers in Healthy Older Adults: A Randomized, Placebo-Controlled Crossover Study.富含硝酸盐的甜菜根汁对健康老年成年人血压、止血和血管炎症标志物的急性影响：一项随机、安慰剂对照交叉研究。

Nutrients. 2017 Nov 22;9(11):1270. doi: 10.3390/nu9111270.

Nitrate-Rich Beetroot Juice Reduces Blood Pressure in Tanzanian Adults with Elevated Blood Pressure: A Double-Blind Randomized Controlled Feasibility Trial.富含硝酸盐的甜菜根汁可降低坦桑尼亚高血压成年人的血压：一项双盲随机对照可行性试验。

J Nutr. 2020 Sep 1;150(9):2460-2468. doi: 10.1093/jn/nxaa170.

A Nitrate-Rich Vegetable Intervention Elevates Plasma Nitrate and Nitrite Concentrations and Reduces Blood Pressure in Healthy Young Adults.富含硝酸盐的蔬菜干预可提高健康年轻成年人的血浆硝酸盐和亚硝酸盐浓度并降低血压。

J Acad Nutr Diet. 2020 Aug;120(8):1305-1317. doi: 10.1016/j.jand.2020.02.014. Epub 2020 May 5.

A Double-Blind Placebo-Controlled Crossover Study of the Effect of Beetroot Juice Containing Dietary Nitrate on Aortic and Brachial Blood Pressure Over 24 h.一项关于含膳食硝酸盐的甜菜根汁对主动脉和肱动脉血压24小时影响的双盲安慰剂对照交叉研究。

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本文引用的文献

Associations of serum betaine with blood pressure and hypertension incidence in middle-aged and older adults: a prospective cohort study.血清甜菜碱与中老年人群血压和高血压发病的相关性：一项前瞻性队列研究。

Food Funct. 2023 May 22;14(10):4881-4890. doi: 10.1039/d3fo00325f.

Long-term dietary nitrate supplementation does not reduce renal cyst growth in experimental autosomal dominant polycystic kidney disease.长期膳食硝酸盐补充剂不会减少实验性常染色体显性多囊肾病的肾囊肿生长。

PLoS One. 2021 Apr 22;16(4):e0248400. doi: 10.1371/journal.pone.0248400. eCollection 2021.

Crystal deposition triggers tubule dilation that accelerates cystogenesis in polycystic kidney disease.晶体沉积引发小管扩张，加速多囊肾病的囊肿发生。

J Clin Invest. 2019 Jul 30;129(10):4506-4522. doi: 10.1172/JCI128503.

The Nitrate-Independent Blood Pressure-Lowering Effect of Beetroot Juice: A Systematic Review and Meta-Analysis.甜菜根汁不依赖硝酸盐的降压作用：系统评价与荟萃分析

Adv Nutr. 2017 Nov 15;8(6):830-838. doi: 10.3945/an.117.016717. Print 2017 Nov.

Gastrointestinal Manifestations of Autosomal-Dominant Polycystic Kidney Disease.常染色体显性遗传多囊肾病的胃肠道表现。

Clin Gastroenterol Hepatol. 2017 Jan;15(1):17-24. doi: 10.1016/j.cgh.2016.06.017. Epub 2016 Jun 29.

Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.膳食硝酸盐可使高血压患者血压持续降低：一项随机、2期、双盲、安慰剂对照研究。

Hypertension. 2015 Feb;65(2):320-7. doi: 10.1161/HYPERTENSIONAHA.114.04675. Epub 2014 Nov 24.

Magnitude of blood pressure reduction in the placebo arms of modern hypertension trials: implications for trials of renal denervation.现代高血压临床试验安慰剂组的血压降低幅度：对肾去神经术临床试验的影响。

Hypertension. 2015 Feb;65(2):401-6. doi: 10.1161/HYPERTENSIONAHA.114.04640. Epub 2014 Nov 17.

Asymmetric dimethylarginine and lipid peroxidation products in early autosomal dominant polycystic kidney disease.常染色体显性遗传性多囊肾病早期的不对称二甲基精氨酸与脂质过氧化产物

Am J Kidney Dis. 2008 Feb;51(2):184-91. doi: 10.1053/j.ajkd.2007.09.020.

Endothelial dysfunction and reduced nitric oxide in resistance arteries in autosomal-dominant polycystic kidney disease.常染色体显性多囊肾病中阻力动脉的内皮功能障碍与一氧化氮减少

Kidney Int. 2003 Oct;64(4):1381-8. doi: 10.1046/j.1523-1755.2003.00236.x.

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Randomized Trial of Nitrate-Replete Beetroot Juice on Blood Pressure in Hypertensive Adults with ADPKD.

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