Antibacterial, antifungal, antidiabetic, and antioxidant activities potential of Coleus aromaticus synthesized titanium dioxide nanoparticles.

The nanoparticles based drug delivery and treatment related research has been increased significantly in the recent years. Hence, the antibacterial, antifungal, and antioxidant activity potential of pre synthesized and characterized Titanium dioxide nanoparticles (TiO NPs) were investigated in this study through respective standard protocols. Interestingly, the obtained results revealed that TiO NPs have concentration dependent antibacterial activity against bacterial pathogens such as E. coli, P.mirabilis, V. cholerae, P. aeruginosa, S. typhimurium, and S. aureus at 100 μg mL concentration. Furthermore, these TiO NPs showed remarkable antifungal activity against aspergillosis causing fungal pathogens such as A. niger, A. fumigatus, A. nidulans, and A. flavus at 100 μg mL concentration. α-glucosidase. This TiO NPs also effectively inhibit the α-amylase (17%) and α-Glucosidase (37%) enzyme activity at 100 μg mL dosage. The DPPH assay revealed that TiO NPs effectively scavenge DPPH free radicals by up to 89% at 100 μg mL concentration, which was comparable to butylated hydroxytoluene (96%). These results suggest that the plant-based TiO NPs have remarkable in-vitro antibacterial, antifungal, and antioxidant activity. These may be considered for additional in-vitro and in-vivo experiments to assess their potential biomedical applications.