Department of Agricultural Economy and Development, Faculty of Agriculture, Chiang Mai University, 50200, Thailand; Innovative Agriculture Research Center, Faculty of Agriculture, Chiang Mai University, Chiang Mai, 50200, Thailand.
Department of Entomology and Plant Pathology, Faculty of Agriculture, Chiang Mai University, 50200, Thailand; Innovative Agriculture Research Center, Faculty of Agriculture, Chiang Mai University, Chiang Mai, 50200, Thailand.
Environ Res. 2023 Jan 1;216(Pt 3):114714. doi: 10.1016/j.envres.2022.114714. Epub 2022 Nov 2.
The nanoparticles based drug delivery and treatment related research has been increased significantly in the recent years. Hence, the antibacterial, antifungal, and antioxidant activity potential of pre synthesized and characterized Titanium dioxide nanoparticles (TiO NPs) were investigated in this study through respective standard protocols. Interestingly, the obtained results revealed that TiO NPs have concentration dependent antibacterial activity against bacterial pathogens such as E. coli, P.mirabilis, V. cholerae, P. aeruginosa, S. typhimurium, and S. aureus at 100 μg mL concentration. Furthermore, these TiO NPs showed remarkable antifungal activity against aspergillosis causing fungal pathogens such as A. niger, A. fumigatus, A. nidulans, and A. flavus at 100 μg mL concentration. α-glucosidase. This TiO NPs also effectively inhibit the α-amylase (17%) and α-Glucosidase (37%) enzyme activity at 100 μg mL dosage. The DPPH assay revealed that TiO NPs effectively scavenge DPPH free radicals by up to 89% at 100 μg mL concentration, which was comparable to butylated hydroxytoluene (96%). These results suggest that the plant-based TiO NPs have remarkable in-vitro antibacterial, antifungal, and antioxidant activity. These may be considered for additional in-vitro and in-vivo experiments to assess their potential biomedical applications.
近年来，基于纳米粒子的药物输送和治疗相关研究显著增加。因此，本研究通过各自的标准方案，研究了预合成和表征的二氧化钛纳米粒子（TiO NPs）的抗菌、抗真菌和抗氧化活性潜力。有趣的是，研究结果表明，TiO NPs 在 100μg/mL 浓度下对大肠杆菌、奇异变形杆菌、霍乱弧菌、铜绿假单胞菌、鼠伤寒沙门氏菌和金黄色葡萄球菌等细菌病原体具有浓度依赖性的抗菌活性。此外，这些 TiO NPs 对黑曲霉、烟曲霉、构巢曲霉和黄曲霉等引起曲霉病的真菌病原体表现出显著的抗真菌活性，在 100μg/mL 浓度下。α-葡萄糖苷酶。这些 TiO NPs 还能有效抑制α-淀粉酶（17%）和α-葡萄糖苷酶（37%）的酶活性，在 100μg/mL 剂量下。DPPH 试验表明，TiO NPs 在 100μg/mL 浓度下可有效清除 DPPH 自由基，清除率高达 89%，与丁基羟基甲苯（96%）相当。这些结果表明，基于植物的 TiO NPs 具有显著的体外抗菌、抗真菌和抗氧化活性。这些可能会被考虑用于额外的体外和体内实验，以评估它们在生物医学应用方面的潜力。
