光滑念珠菌是一种成功的病原体：一位操控免疫反应的“艺术家”。

Candida glabrata is a successful pathogen: An artist manipulating the immune response.

作者信息

Shantal Castrejón-Jiménez Nayeli, Juan Castillo-Cruz, Lizbeth Baltierra-Uribe Shantal, Carlos Hernández-González Juan, Estela García-Pérez Blanca

机构信息

Área Académica de Medicina Veterinaria y Zootecnia, Instituto de Ciencias Agropecuarias Universidad Autónoma del Estado de Hidalgo, Av. Universidad km. 1. Exhacienda de Aquetzalpa A.P. 32, 43600 Tulancingo, Hidalgo, Mexico.

Instituto Politécnico Nacional, Escuela Nacional de Ciencias Biológicas, Departamento de Microbiología, Prolongación de Carpio y Plan de Ayala s/n, 11340 Ciudad de México, Mexico.

出版信息

Microbiol Res. 2022 Jul;260:127038. doi: 10.1016/j.micres.2022.127038. Epub 2022 Apr 11.

DOI:10.1016/j.micres.2022.127038

PMID:35430489

Abstract

In recent years, Candida glabrata has emerged as a clinically important pathogen causing invasive infections and death. This review highlights the main virulence factors of this fungus and its strategies to subvert the cell response after invasion. Additionally, we emphasize the intracellular behavior and relationship of C. glabrata with several cells. We contrast these features with some fascinating strategies exhibited by M. tuberculosis to highlight that C. glabrata is a successful pathogen and an artist manipulating the immune response like M. tuberculosis.

摘要

近年来，光滑念珠菌已成为一种引起侵袭性感染和死亡的重要临床病原体。本综述重点介绍了这种真菌的主要毒力因子及其入侵后颠覆细胞反应的策略。此外，我们强调了光滑念珠菌在细胞内的行为及其与几种细胞的关系。我们将这些特征与结核分枝杆菌展示的一些引人入胜的策略进行对比，以突出光滑念珠菌是一种成功的病原体，并且像结核分枝杆菌一样是操纵免疫反应的“艺术家”。