• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

心理学中的扰动图、不变因果预测与因果关系

Perturbation graphs, invariant causal prediction and causal relations in psychology.

作者信息

Waldorp Lourens, Kossakowski Jolanda, van der Maas Han L J

机构信息

University of Amsterdam, Amsterdam, The Netherlands.

出版信息

Br J Math Stat Psychol. 2025 Feb;78(1):303-340. doi: 10.1111/bmsp.12361. Epub 2024 Oct 21.

DOI:10.1111/bmsp.12361
PMID:39431891
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11701423/
Abstract

Networks (graphs) in psychology are often restricted to settings without interventions. Here we consider a framework borrowed from biology that involves multiple interventions from different contexts (observations and experiments) in a single analysis. The method is called perturbation graphs. In gene regulatory networks, the induced change in one gene is measured on all other genes in the analysis, thereby assessing possible causal relations. This is repeated for each gene in the analysis. A perturbation graph leads to the correct set of causes (not nec-essarily direct causes). Subsequent pruning of paths in the graph (called transitive reduction) should reveal direct causes. We show that transitive reduction will not in general lead to the correct underlying graph. We also show that invariant causal prediction is a generalisation of the perturbation graph method and does reveal direct causes, thereby replacing transitive re-duction. We conclude that perturbation graphs provide a promising new tool for experimental designs in psychology, and combined with invariant causal prediction make it possible to re-veal direct causes instead of causal paths. As an illustration we apply these ideas to a data set about attitudes on meat consumption and to a time series of a patient diagnosed with major depression disorder.

摘要

心理学中的网络(图)通常局限于无干预的情境。在此,我们考虑一种借鉴自生物学的框架,该框架在单一分析中涉及来自不同情境(观察和实验)的多种干预。这种方法被称为扰动图。在基因调控网络中,对分析中的一个基因的诱导变化会在所有其他基因上进行测量,从而评估可能的因果关系。对分析中的每个基因都重复此操作。一个扰动图会得出正确的因果集(不一定是直接原因)。随后对图中的路径进行修剪(称为传递简约)应能揭示直接原因。我们表明,传递简约通常不会得出正确的基础图。我们还表明,不变因果预测是扰动图方法的一种推广,并且确实能揭示直接原因,从而取代传递简约。我们得出结论,扰动图为心理学实验设计提供了一种有前景的新工具,并且与不变因果预测相结合能够揭示直接原因而非因果路径。作为例证,我们将这些想法应用于一个关于肉类消费态度的数据集以及一位被诊断患有重度抑郁症患者的时间序列。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c322/11701423/0fc9a71fffe4/BMSP-78-303-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c322/11701423/a49c38106c1f/BMSP-78-303-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c322/11701423/5eebcdcd5b76/BMSP-78-303-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c322/11701423/2d20147038fd/BMSP-78-303-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c322/11701423/746ef1117812/BMSP-78-303-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c322/11701423/7771b25c04f8/BMSP-78-303-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c322/11701423/069d6bedb58f/BMSP-78-303-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c322/11701423/dd247a1a0a0e/BMSP-78-303-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c322/11701423/f62224abef01/BMSP-78-303-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c322/11701423/0fc9a71fffe4/BMSP-78-303-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c322/11701423/a49c38106c1f/BMSP-78-303-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c322/11701423/5eebcdcd5b76/BMSP-78-303-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c322/11701423/2d20147038fd/BMSP-78-303-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c322/11701423/746ef1117812/BMSP-78-303-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c322/11701423/7771b25c04f8/BMSP-78-303-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c322/11701423/069d6bedb58f/BMSP-78-303-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c322/11701423/dd247a1a0a0e/BMSP-78-303-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c322/11701423/f62224abef01/BMSP-78-303-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c322/11701423/0fc9a71fffe4/BMSP-78-303-g007.jpg

相似文献

1
Perturbation graphs, invariant causal prediction and causal relations in psychology.心理学中的扰动图、不变因果预测与因果关系
Br J Math Stat Psychol. 2025 Feb;78(1):303-340. doi: 10.1111/bmsp.12361. Epub 2024 Oct 21.
2
The search for causality: A comparison of different techniques for causal inference graphs.对因果关系的探寻:因果推断图不同技术的比较
Psychol Methods. 2021 Dec;26(6):719-742. doi: 10.1037/met0000390. Epub 2021 Jul 29.
3
Reconstruction of large-scale regulatory networks based on perturbation graphs and transitive reduction: improved methods and their evaluation.基于扰动图和传递简约的大规模调控网络重建:改进方法及其评估
BMC Syst Biol. 2013 Aug 8;7:73. doi: 10.1186/1752-0509-7-73.
4
Assessing statistical significance in causal graphs.评估因果图中的统计显著性。
BMC Bioinformatics. 2012 Feb 20;13:35. doi: 10.1186/1471-2105-13-35.
5
Developing a novel causal inference algorithm for personalized biomedical causal graph learning using meta machine learning.利用元机器学习开发个性化生物医学因果图学习的新因果推理算法。
BMC Med Inform Decis Mak. 2024 May 27;24(1):137. doi: 10.1186/s12911-024-02510-6.
6
TRANSWESD: inferring cellular networks with transitive reduction.TRANSWESD:使用传递约简推断细胞网络。
Bioinformatics. 2010 Sep 1;26(17):2160-8. doi: 10.1093/bioinformatics/btq342. Epub 2010 Jul 6.
7
Causal graphical views of fixed effects and random effects models.固定效应模型和随机效应模型的因果图形视图。
Br J Math Stat Psychol. 2021 May;74(2):165-183. doi: 10.1111/bmsp.12217. Epub 2020 Oct 15.
8
Dialogue and causality: global description from local observations and vague communications.对话与因果关系:基于局部观察和模糊交流的全局描述
Biosystems. 2007 Nov-Dec;90(3):783-91. doi: 10.1016/j.biosystems.2007.04.001. Epub 2007 Apr 21.
9
Causal inference in biology networks with integrated belief propagation.基于集成信念传播的生物网络因果推断
Pac Symp Biocomput. 2015:359-70.
10
Identifying miRNA-mRNA regulatory relationships in breast cancer with invariant causal prediction.利用不变因果预测识别乳腺癌中的 miRNA-mRNA 调控关系。
BMC Bioinformatics. 2019 Mar 15;20(1):143. doi: 10.1186/s12859-019-2668-x.

本文引用的文献

1
The search for causality: A comparison of different techniques for causal inference graphs.对因果关系的探寻:因果推断图不同技术的比较
Psychol Methods. 2021 Dec;26(6):719-742. doi: 10.1037/met0000390. Epub 2021 Jul 29.
2
Network outcome analysis identifies difficulty initiating sleep as a primary target for prevention of depression: a 6-year prospective study.网络结局分析将入睡困难确定为预防抑郁的主要目标:一项 6 年的前瞻性研究。
Sleep. 2020 May 12;43(5). doi: 10.1093/sleep/zsz288.
3
Robust network inference using response logic.基于响应逻辑的稳健网络推断。
Bioinformatics. 2019 Jul 15;35(14):i634-i642. doi: 10.1093/bioinformatics/btz326.
4
An Introduction to Network Psychometrics: Relating Ising Network Models to Item Response Theory Models.网络心理计量学导论:将伊辛网络模型与项目反应理论模型相关联。
Multivariate Behav Res. 2018 Jan-Feb;53(1):15-35. doi: 10.1080/00273171.2017.1379379. Epub 2017 Nov 7.
5
Network Structure Explains the Impact of Attitudes on Voting Decisions.网络结构解释了态度对投票决策的影响。
Sci Rep. 2017 Jul 7;7(1):4909. doi: 10.1038/s41598-017-05048-y.
6
A network theory of mental disorders.精神障碍的网络理论。
World Psychiatry. 2017 Feb;16(1):5-13. doi: 10.1002/wps.20375.
7
Methods for causal inference from gene perturbation experiments and validation.基因扰动实验因果推断及验证方法。
Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7361-8. doi: 10.1073/pnas.1510493113.
8
Critical Slowing Down as a Personalized Early Warning Signal for Depression.临界减速作为抑郁症的个性化早期预警信号。
Psychother Psychosom. 2016;85(2):114-6. doi: 10.1159/000441458. Epub 2016 Jan 26.
9
Inferring regulatory networks by combining perturbation screens and steady state gene expression profiles.通过结合扰动筛选和稳态基因表达谱来推断调控网络。
PLoS One. 2014 Feb 28;9(2):e82393. doi: 10.1371/journal.pone.0082393. eCollection 2014.
10
Reconstruction of large-scale regulatory networks based on perturbation graphs and transitive reduction: improved methods and their evaluation.基于扰动图和传递简约的大规模调控网络重建:改进方法及其评估
BMC Syst Biol. 2013 Aug 8;7:73. doi: 10.1186/1752-0509-7-73.