Zhu Boyu, Zhu Lihang, Li Xinru, Zhao Ziyi, Cao Jiayi, Qi Min, Gao Zhigang, Zhou Lin, Su Bin
Institute of Analytical Chemistry, Department of Chemistry, Zhejiang University, Hangzhou 310058, China.
Department of Clinical Engineering, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China.
Research (Wash D C). 2024 Oct 21;7:0508. doi: 10.34133/research.0508. eCollection 2024.
Exercise is one of the preferred management strategies for diabetic patients, but the exercise mode including type, intensity, and duration time is quite different for each patient because of individual differences. Inadequate exercise has no effect on the blood glucose control, while overexercise may cause serious side effects, such as hypoglycemia and loss of blood glucose control. In this work, we report a closed-loop feedback mode for exercise management in diabetes. A minimally invasive, biocompatible microneedle electrode patch was fabricated and used for continuously monitoring the glucose in the interstitial fluid. Further, in conjunction with using a wireless electrochemical device, the glucose signals can be analyzed to output the potency of exercise and give advice on exercise management. A custom exercise given by this closed-loop feedback mode can reduce the used dose of insulin and avoid side effect during and after exercise. We believe that this work can provide a novel comprehensive guidance for diabetic patients.
运动是糖尿病患者首选的管理策略之一，但由于个体差异，每个患者的运动模式（包括类型、强度和持续时间）差异很大。运动不足对血糖控制没有影响，而过度运动可能会导致严重的副作用，如低血糖和血糖控制丧失。在这项工作中，我们报告了一种用于糖尿病运动管理的闭环反馈模式。制造了一种微创、生物相容性微针电极贴片，并用于连续监测间质液中的葡萄糖。此外，结合使用无线电化学装置，可以分析葡萄糖信号以输出运动强度并提供运动管理建议。这种闭环反馈模式给出的定制运动可以减少胰岛素的使用剂量，并避免运动期间和运动后的副作用。我们相信这项工作可以为糖尿病患者提供一种新颖的全面指导。
