Four New Tirucallane Triterpenoids from the Leaves of Ailanthus Triphysa with Anti-Inflammatory Activities.
作者信息
Duc Duy Nguyen, Thi Dung Duong, Thi Trang Do, Anh Bang Ngo, Hai Yen Pham, Xuan Nhiem Nguyen, Thi Cuc Nguyen, Thanh Huong Phan Thi, Viet Dung Nguyen, Huy Hoang Nguyen, Thi Hai Yen Duong, Thi Kim Thuy Nguyen, The Cuong Nguyen, Huu Tai Bui, Van Kiem Phan
机构信息
Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam.
Center for High Technology Research and Development, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam.
出版信息
Chem Biodivers. 2025 Mar;22(3):e202402584. doi: 10.1002/cbdv.202402584. Epub 2024 Nov 14.
Isolation and determination of three new compounds from the leaves of Ailanthus triphysa (Dennst.) Alston with their anti-inflammatory activity. Ten tirucallane triterpenes (1-10) including four undescribed compounds, ailantriphysas A-D (1-4), were isolated from the leaves of Ailanthus triphysa (Dennst.) Alston. Their structures were elucidated using IR, HR-ESI-MS, 1D- and 2D-NMR spectra. Compound 1 inhibited lipopolysaccharide(LPS)-induced nitric oxide production in RAW 264.7 cells with an IC value of 8.1±μM. Additionally, compound 1 also displayed significant inhibitory effects on the secretion of IL-6 and TNF-α at tested concentrations of 4, 8, and 16 μM.
Zotero 插件