来自[植物名称]叶子的新型三萜类化合物及其抗炎活性。 （你提供的原文中“from the Leaves of ”后面缺少具体植物名称）
New Triterpenoids from the Leaves of and Their Anti-Inflammatory Activity.
作者信息
Ren Chenyang, Liang Xiaoqin, Pi Rui, Xin Jiwen, Yang Bo, Zheng Qingfang, Li Yanqin, Li Jun, Zhang Yanjun
机构信息
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China.
Guangxi Key Laboratory of Green Chemical Materials and Safety Technology, College of Petroleum and Chemical Engineering, Beibu Gulf University, Qinzhou 535000, China.
出版信息
Molecules. 2024 Dec 31;30(1):131. doi: 10.3390/molecules30010131.
Six new triterpenoids, heritieras C-H (-), along with thirteen known triterpenoids (-), were isolated from the leaves of . Their structures were identified by spectroscopic analysis, including 1D and 2D nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry (HRESIMS), and by comparison with the literature. Anti-inflammatory activity of the isolates was evaluated using the lipopolysaccharide (LPS) stimulated RAW 264.7 cell model. Among the isolated triterpenoid, compounds , , , , and demonstrated inhibitory activity against nitric oxide (NO) release, in which compound exhibited the best activity with an IC value of 18.13 μM. The potential anti-inflammatory mechanism was investigated using molecular docking. The triterpenoids from could be served as potential candidates for the development of new anti-inflammatory agents.
从[植物名称]的叶子中分离出六个新的三萜类化合物，即海桑C-H（-），以及十三个已知的三萜类化合物（-）。通过光谱分析，包括一维和二维核磁共振（NMR）、高分辨率电喷雾电离质谱（HRESIMS），并与文献进行比较，确定了它们的结构。使用脂多糖（LPS）刺激的RAW 264.7细胞模型评估了分离物的抗炎活性。在分离出的三萜类化合物中，化合物[具体化合物编号1]、[具体化合物编号2]、[具体化合物编号3]、[具体化合物编号4]和[具体化合物编号5]表现出对一氧化氮（NO）释放的抑制活性，其中化合物[具体化合物编号5]表现出最佳活性，IC值为18.13μM。使用分子对接研究了潜在的抗炎机制。来自[植物名称]的三萜类化合物可作为开发新型抗炎药物的潜在候选物。
Zotero 插件