川莓根中的三萜皂苷及其体外抗炎活性
Triterpenoid saponins from Rubus setchuenensis roots and their anti-inflammatory activities in vitro.
作者信息
Lei Yueyue, Xu Dawei, Wang Yuexuan, Guo Shiwen, Li Lujun, Luo Mengyin, Li Xu, Liu Xinyi, Shi Chunyang
机构信息
National & Local Joint Engineering Research Center of High-throughput Drug Screening Technology, State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Key Laboratory of Biotechnology of Chinese Traditional Medicine, College of Health Science and Engineering, Hubei University, Wuhan, 430062, China.
National & Local Joint Engineering Research Center of High-throughput Drug Screening Technology, State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Key Laboratory of Biotechnology of Chinese Traditional Medicine, College of Health Science and Engineering, Hubei University, Wuhan, 430062, China.
出版信息
Phytochemistry. 2025 May;233:114403. doi: 10.1016/j.phytochem.2025.114403. Epub 2025 Jan 18.
Previously undescribed triterpenoid saponins (1-8), along with eight previously reported analogues (9-16), were isolated from an EtOAc extract obtained from the roots of Rubus setchuenensis. Structures were established based on HRESIMS, 1D and 2D NMR, as well as by literature comparisons. All compounds were isolated for the first time from the genus Rubus. Compounds 3-4, 6-8, and 12-15 displayed inhibitory activities against NO production in a RAW264.7 cell inflammation model induced by LPS. Moreover, 4, 6-8, and 12-13 exhibited inhibitory effects in a LPS-induced BV-2 cell neuroinflammation model.
从川莓根的乙酸乙酯提取物中分离得到了此前未描述过的三萜皂苷（1-8）以及八个先前报道过的类似物（9-16）。通过高分辨电喷雾电离质谱（HRESIMS）、一维和二维核磁共振（1D和2D NMR）以及文献比较确定了其结构。所有化合物均首次从悬钩子属植物中分离得到。化合物3-4、6-8和12-15在脂多糖（LPS）诱导的RAW264.7细胞炎症模型中表现出对一氧化氮（NO）生成的抑制活性。此外，化合物4、6-8和12-13在LPS诱导的BV-2细胞神经炎症模型中表现出抑制作用。
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