Van Ngoc Nguyen, Ngoc Uyen Nhi Tran, Thi Binh Hoang
Faculty of Biology, Dalat University, Dalat, Lam Dong, 670000, Vietnam.
Chem Biodivers. 2025 Mar;22(3):e202402472. doi: 10.1002/cbdv.202402472. Epub 2024 Nov 18.
An analysis was conducted on the essential oil extracted from the leaves of Magnolia bidoupensis utilizing GC-MS, revealing thirty-three constituents that account for 98.9 % of the essential oil. The main components included pogostol (22.4 %), δ-selinene (16.2 %), and α-amorphene (14.7 %). Bioassays were then performed to evaluate the oil's biological activity. The essential oil exhibited antimicrobial activity against all tested microorganisms (six bacterial strains and one fungal strain) using the minimum inhibitory concentration (MIC) method. Additional cytotoxicity tests were conducted on KB, HepG2, MCF-7, and A549 cancer cell lines using the MTT method. The essential oil exhibited strong cytotoxic effects on all four cell lines, with IC values ranging from 1.37±0.05 μg/mL (KB) to 2.40±0.06 μg/mL (A549).
利用气相色谱 - 质谱联用仪（GC - MS）对从大围山木兰叶片中提取的精油进行了分析，结果显示该精油含有33种成分，占精油总量的98.9%。主要成分包括广藿香醇（22.4%）、δ-芹子烯（16.2%）和α-香树烯（14.7%）。随后进行了生物测定以评估该精油的生物活性。采用最低抑菌浓度（MIC）法，该精油对所有测试微生物（6种细菌菌株和1种真菌菌株）均表现出抗菌活性。使用MTT法对KB、HepG2、MCF - 7和A549癌细胞系进行了额外的细胞毒性测试。该精油对所有四种细胞系均表现出强烈的细胞毒性作用，IC值范围为1.37±0.05μg/mL（KB）至2.40±0.06μg/mL（A549）。
