Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States of America.
Department of Biology, Brigham Young University, Provo, UT, United States of America.
PLoS One. 2024 Oct 23;19(10):e0312549. doi: 10.1371/journal.pone.0312549. eCollection 2024.
Human papillomavirus (HPV) causes an estimated 300,000 high grade cervical dysplasias and 36,000 preventable cancers each year in the United States alone. Despite having a safe, effective and long lasting vaccine since 2006, the rate of uptake has been suboptimal, particularly in rural areas. In 2020, Utah ranked near last in teenage HPV vaccination rates with rural areas trailing urban areas by about 18 percent. In this study, we identified factors that affect the intent of rural Utah parents to vaccinate their children against HPV.
A survey was distributed electronically to Utah residents in rural areas. Recruitment was carried out through targeted advertising, community organizations, and professional survey panels. The survey was open from Nov. 15, 2022 to April 15, 2023. A total of 410 respondents were used for analysis. Survey results were analyzed using exploratory factor analysis, confirmatory factor analysis, and structural equation modeling.
Distance to care was shown to negatively influence direct intent to vaccinate, while trust in government, general vaccine attitudes, and HPV knowledge positively influence intent to vaccinate. It was found that religious practice decreased vaccine hesitancy while cautious sexual attitudes, distance to care, and general negative vaccine attitudes increased vaccine hesitancy. Conservative political identity and high income were both shown to decrease vaccine hesitancy as covariates.
仅在美国,人乳头瘤病毒(HPV)每年导致约 30 万例高级别宫颈发育不良和 3.6 万例可预防癌症。尽管自 2006 年以来已经有了一种安全、有效且持久的疫苗,但接种率仍不理想,特别是在农村地区。2020 年,犹他州青少年 HPV 疫苗接种率接近全美倒数第一,农村地区比城市地区落后约 18%。在这项研究中,我们确定了影响犹他州农村地区父母为孩子接种 HPV 疫苗意愿的因素。
一项调查通过电子方式分发给犹他州农村地区的居民。通过有针对性的广告、社区组织和专业调查小组进行招募。该调查于 2022 年 11 月 15 日至 2023 年 4 月 15 日开放。共有 410 名受访者用于分析。使用探索性因素分析、验证性因素分析和结构方程模型对调查结果进行分析。
研究发现,就医距离会对直接接种意愿产生负面影响,而对政府的信任、对一般疫苗的态度和 HPV 知识则会对接种意愿产生积极影响。研究还发现,宗教实践会降低疫苗犹豫,而谨慎的性态度、就医距离和一般的负面疫苗态度会增加疫苗犹豫。保守的政治身份和高收入都被证明可以作为协变量降低疫苗犹豫。